大黄在小儿重症肺炎治疗中肠道保护的作用

Clinical Observation of Intestinal Protection by Rhubarb on Treatment of Infantile Severe Pneumonia

目的:探讨大黄在小儿重症肺炎治疗中的肠道保护作用。方法:选择小儿重症肺炎60例.随机分成治疗组和对照组,均采用综合治疗,对照组按西药常规治疗,治疗组内服大黄。结果:治疗组有效率为77%(23/30).对照组有效率为50%(15/30),有统计学差异(P<0.05)。多器官功能障碍(MODS)的发生率治疗组(8/30)占27%;对照组(16/30)占57%.有统计学差异(P<0.05)。治疗组存活26例,生存率86.7%,对照组存活20例,生存率66.7%(P>0.05)。结论:大黄对肠道屏障保护在治疗小儿重症肺炎是行之有效的,可以防止病情向MODS演变及降低病死率。

Objective： To explore the intestinal protection of Rhubarb on treatment of infantile severe pneumonia. Method： Sixty cases of children with severe pneumonia were divided randomly into treated group and control group, both used synthetic treatment, the control group used western medicine conventionally, the treated group was taken Rhubarb by orally. Result： The effective rate of treated group was 77% （23/30）and while the control group was 50% （ 15/30 ） （P 〈 0.05 ）, the difference was statistically. The occurance rate of multiple organ dysfunction syndrome （ MODS ） in treated group was 27 % （8/30） and control group was 57 % （ 16/30 ）, it had statisti- cal difference. The survival rate of treated group was 86.7% and the control group was 66.7% （ P 〉 0.05 ）, there were no statistical difference（ P 〉 0.05 ）. Conclusion： The intestinal protection of Rhubarb on infantile with severe pneumonia is effectively and Rhubarb can prevent the occurance of MODS, reduce the death rate.