焦虑性障碍与痛觉阈值的相关性研究

Correlative study between anxiety disorder and pain perception threshold.

探索焦虑性神经症病人焦虑性障碍与痛觉阈值改变的相关性。方法采用无损伤性高频皮肤电刺激，测定２３例焦虑性神经症病人和２３例年龄和性别匹配的正常对照组的躯体感觉阈（ＳＰＴ）、痛觉阈（ＰＰＴ）及相对痛觉阈ＯＲＰＰＴ）；同时对病人组评定焦虑自评量表（ＳＡＳ）。结果焦虑性神经症病人ＰＰＴ明显高于正常对照组（Ｐ＜０．０５）；ＰＰＴ与ＳＡＳ标准分呈极显著负相关（Ｐ＜０．０００５）。结论焦虑性障碍的病理基础与人类内源性疼痛调节系统可能有紧密的生物学联系。

Objective To explore the correlation between anxiety disorder and pain perception threshold on anxiety neurosis patients.Methods Somatosensory perception threshold (SPT), pain perception threshold (PPT) and the relative pain perception threshold(RPPT) were studied in 23 patients with anxiety neurosis, compared with the findings in an age matched and gender matched control group and related to the psychopathological state evaluated by means of the Salf Rating Anxiety Scale (SAS).Results PPT was increased marhedly in the patients (P<0.05); the changes of PPT were significantly negatively correlated to the SAS scores (P<0.005).Conclusions The date suggested that the pathological base of anxiety disorder might be linked to endogenous pain modulating system in humans on biology.