动态血糖监测评价门冬胰岛素30与中性可溶性人胰岛素30R降糖疗效的研究

Appraising the clinical curative effect of insulin aspart 30 injection in continuous glucose monitoring system

目的应用动态血糖监测系统(dynamic glucose monitoring system,DGMS)评价门冬胰岛素30(Asp30)的有效性和安全性。方法采用随机交叉试验设计,将2005年12月至2007年12月秦皇岛市第一医院的20例2型糖尿病患者随机分为A、B两组,A、B两组分别交叉应用Asp30和中性可溶性人胰岛素30R(30R)控制血糖,同时应用DGMS监测血糖。结果应用Asp30早餐后血糖、晚餐后血糖、早餐后60min皮下组织葡萄糖浓度、早餐后120min皮下组织葡萄糖浓度、晚餐后60min皮下组织葡萄糖浓度、晚餐后120min皮下组织葡萄糖浓度、平均最大皮下组织葡萄糖浓度、三餐后5h内皮下组织平均葡萄糖曲线下面积、DGMS24h曲线下面积均显著小于应用30R组(P<0.05)。应用Asp30低血糖发生共1例次,应用30R低血糖发生共5例次。结论应用Asp30每日2次皮下注射有效的控制24h血糖,减少了餐后血糖的漂移,很少发生低血糖。

Objective To appraise the efficacy and safety of insulin aspart 30 injection by DGMS. Methods Random and crossover trial were designed. Twenty cases with type 2 diabetes mellitus in the First Hospital, Qin Huangdao from December,2005 to December,2007 were randomly divided into group A and group B,which were to individually crosswise control the blood glucose with insulin aspart 30 injection and Novolin 30R. At the same time DGMS was applied to monlto- ring the subcutanea glucose. Results There were significant differences between applying insulin aspart 30 injection and applying Novolin 30R in postprandial 2 hours blood glucose after breakfast and supper, postprandial 1 hour subcutanea glucose after breakfast and supper, postprandial 2 hours subcutanea glucose after breakfast and supper, the average most subcutanea glucose, the area below the curve of average subcutanea glucose during postprandial 5 hours, the area below the curve of subcutanea glucose during 24 h （P 〈 0. 05 ） , which were all lower than applying Novolin 30R. The hypoglucose e- vent were five man-times in total in applying Novolin 30R, however one man-time in applying insulin aspart 30 injection. Conclusion Applying insulin aspart 30 subcutaneous injection twice a day can effectively control the blood glucose in 24 hours, and decrease the drift of postprandial glucose. The hypoglucose event seldom happens.