Ki-67在垂体瘤、脑膜瘤、脑血管母细胞瘤中的表达及其临床意义

Clinical Significance of Ki-67 Expression in Pituitary Adenomas, Meningiomas and Hemangioblastomas

背景与目的:垂体瘤、脑膜瘤和脑血管母细胞瘤作为颅内常见良性肿瘤,术后常有复发,本研究探讨Ki-67在三者中的表达及其与复发的关系。方法:采用免疫组化SP法,检测Ki-67在56例垂体瘤、60例脑膜瘤和43例脑血管母细胞瘤中的表达,以显微镜下细胞核出现棕黄色颗粒计算Ki-67标记指数,并进行统计学分析。结果:Ki-67表达在垂体瘤侵袭性组高于非侵袭性组,脑膜瘤与脑血管母细胞瘤的复发组高于非复发组,差异均有统计学意义(P<0.05)。结论:检测垂体瘤、脑膜瘤和脑血管母细胞瘤中Ki-67表达对评估肿瘤术后复发有一定参考价值。

BACKGROUND ＆ OBJECTIVE： To explore the relationship between Ki-67 expression and the reeurrenee of pituitary adenomas, rueningiomas and hemangioblastomas. METHODS： The immunohistochemical method was applied to deteet the expression of Ki-67 in 56 pituitary adenomas, 60 meningiomas and 43 hemangioblastomas. RESULTS： Expression of Ki-67 was signifieantly higher in invasive pituitary adenomas group than that in noninvasive group （P〈0.05）, and there was also a significant differenee in expression of Ki-67 between the recurrent group and nonreeurrent group of both meningiomas and hemangioblastomas （P 〈0.05）. CONCLUSION： The expression of Ki-67 may be helpful to prediet the reeurrenee of pituitary adenomas, meningiomas and hemangioblastomas.