下颌骨外板与颅骨外板移植后吸收率的比较研究

Comparative study of oniay bone graft absorption of outer cortex from mandible and cranium

目的通过比较下颌骨外板与颅骨外板移植后的吸收率，以为下颌骨外板在临床应用提供理论依据。方法8～12个月龄成年小香猪8只，分别截取一侧下颌骨外板及部分颅顶部外板并修整成相同大小（2．5cm×1．0cm），用排水法测量体积后将两骨块贴附植于鼻拱部两侧。随机挑选2只动物，于术后12周处死，取下颌骨外板及颅骨外板贴附植骨区各1．5cm×0．5cm大小骨质标本行组织学检查；另6只动物于术后24周处死，用印模材料翻制移植骨块模型后用排水法测量其体积，同时取骨质标本行组织学检查。结果下颌骨外板贴附移植后总体吸收率为（41±5）％．颅骨外板为（46±12）％，两者比较差异无统计学意义（P=0．51），移植骨愈合改建过程与颅骨外板一致。结论下颌骨外板是颅面部贴附植骨良好的自体骨源。

Objective To investigate the value of application of mandibular outer cortex as bone graft by comparing its bone absorption with cranial outer cortex, Methods 8 minltype grown-up pigs at the age of 8～12months underwent surgery of taking out the same size（2.5 cm× 1.0 cm） of outer cortex from mandible and craninium. The volume of the outer cortex was measured by volume-displacement method. Then the outer cortex of mandible and cranium were onlay grafted to the each side of the pig snout, respectively, 12 weeks later, 2 pigs were randomly selected for histological examination. The other 6 pigs were killed 24 weeks after surgery for measurement of the bone graft volume and histologic examination. Results The bone graft absorption rate was （41 ± 5）% for mandibular outer cortex and （46 ± 12）% for cranial outer cortex, showing no significant difference between them （ P = 0.51 ） , The histologic examination results also had no marked difference in the bony healing and reforming between the two graft. Conclusions Mandibular outer cortex is a good donor site for onlay bone graft in craniofacial region.