子宫内膜癌pS2、Cathepsin-D、甾体受体的表达及意义

Expression of pS2,Cathepsin D,Steroid Receptors,and Their Significance in Endometrial Cancer

目的:观察子宫内膜癌中雌激素调节蛋白(pS2)、组织蛋白酶D(cath-D)、孕激素受体(PR)、雌激素受体-α(ER-α)表达情况,并探讨其与子宫内膜癌的临床病理特征和预后的关系。方法:应用免疫组化检测91例子宫内膜癌组织中pS2、cath-D、PR、ER-α的表达。结果:pS2、cath-D、PR、ER-α阳性率分别为30.8%、34.1%、68.1%、54.9%。pS2阳性、PR阳性与肿瘤高分化、肌层浸润浅、FIGO分期早有关,pS2阳性、PR阳性患者生存期较长。cath-D阳性与肿瘤低分化、肌层浸润深、宫颈受累、FIGO分期晚有关,cath-D阳性患者生存期较短。ER-α与各种临床病理特征和生存期无关。多因素分析显示PR为患者生存期最强的影响因素。结论:pS2阳性、PR阳性、cath-D阴性患者与好的临床病理特征有关,患者生存期长,预后好。

Objective：To determine the expression of pS2, Cathespin D （cath- D）, progesterone receptor （PR）, and estrogen receptor （ ER-α） in patients of endometrial carcinoma, and approach their predictive values for clinicopathological characteristics and prognosis.Methods： Immunohistochemistry was used to measure the pS2, cath- D, PR, and ER-α protein levels in endornetrlal carcinoma tissue of 91 patients. Results： Out of the 91 pa- tients, 28（30.8%）, 31（34.1%）, 62（68.1%）, and 50（54.9%） were positive for pS2, cath-D, PR, and ER-α, respectively. The positive pS2 and PR were significantly related with lower grade, superficial myometrial invasion, earlier FIGO stage, and longer survival time. The positive cath - D was significantly related with higher grade, deeper myometrial invasion, cervical involvement, late FIGO stage, and shorter survival time. However, ER positive hadn＇t related with clinicopathological factors and survival, In multiplicity, PR appeared to be the most powerful prognostic factor associated with survival. Conclusions： pS2 positive, cath- D negative, and PR positive are significantly related with better clinicopathological characteristics with longer survival time.