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RPS12基因表达与胃癌进展及淋巴结转移的研究

Study on the Relationship of RPS12 Expression with the Progression and Lymph Node Metastasis of Gastric Cancers
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摘要 目的探讨核糖体蛋白S12(RPS12)基因表达与胃癌进展及淋巴结转移的关系。方法采用原位杂交方法检测39例进展期胃癌组织、17例正常胃黏膜中RPS12mRNA表达。结果胃癌中RPS12mRNA表达阳性表达率(87.2%)显著高于正常胃黏膜(17.6%),P<0.01;淋巴结转移阳性的胃癌中RPS12mRNA表达阳性率(96.2%)显著高于淋巴结转移阴性者(69.2%),P<0.05。结论RPS12基因高表达与胃癌进展及淋巴结转移有关。 Objective To study the relationship of RPS12 expression with the progression and lymph node metastasis of gastric cancers. Methods The RPS12 mRNA expressions in 39 cases of advanced gastric cancer and 17 cases of normal gastric mucosa were detected by in situ hybridization. Results The positive rate of RPS12 mRNA expression in gastric cancers （87.2%）was significantly higher than that in normal gastric mucosa （17.6%）,P 〈 0.01. The positive rate of RPS12 mRNA expression in gastric cancers with lymph node metastasis （96.2%）was significantly higher than that without lymph node metastasis （69.2%）, P 〈 0.05. Conclusion The high expression of RPS12 is correlated with the progression and lymph node metastasis of gastric cancer.
作者 刘言厚 孙秀菊 付浩 郑志红 陈芳杰 徐惠绵 王梅先 孙开来
机构地区 中国医科大学基础医学院医学遗传学教研室 庄河市中心医院病理科 沈阳医学院生化教研室 中国医科大学实验动物中心 中国医科大学附属第一医院肿瘤科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2008年第4期522-523,共2页 Journal of China Medical University
基金 国家自然科学基金资助项目(30570848) 国家重点基础研究发展规划项目(973)(G1998051203) 辽宁省自然科学基金资助项目(20032075)
关键词 核糖体蛋白S12 胃癌 原位杂交 RPS12 gene gastric cancer in situ hybridization
分类号 R735.2 [医药卫生—肿瘤]
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参考文献7

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中国医科大学学报
2008年 第4期

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