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滤泡树突状细胞及相关细胞标志物在淋巴结中的分布 被引量：2

Distribution of Follicular Dendritic Cells and Related Cell Markers in the Lymph Node
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摘要 目的研究滤泡树突状细胞(FDC)及相关细胞标志物在淋巴结中的分布。方法用HE染色方法和免疫组织化学方法检测正常淋巴结中FDC、CD20+细胞、趋化因子受体CXCR4+细胞、CD38+细胞的分布情况。结果正常淋巴结被膜下分布着多个生发中心,其内可见FDC网络,与CD20+B细胞分布一致;CXCR4+细胞、CD38+细胞主要分布在生发中心帽区,在生发中心明区和淋巴小结间区亦有少量表达。结论FDC网络周围分布着大量CXCR4+细胞、CD38+细胞,这种分布形式为人类免疫缺陷病毒(HIV)感染、复制等提供了便利条件,与HIV致病机制密切相关,应成为HIV感染的主要研究靶点。 Objective To investigate the distribution of follicular dentritic cells （ FDC ） and related cell makers in the lymph node. Methods HE-staining and immunohistochemical staining were performed to study the distribution of follicular dentritic cells,CD20^＋ cells, chemokine receptor CXCR4^＋ cells and CD38^＋ cells in normal lymph nodes. Results Many germinal centers were observed under lymph node capsule,in which FDC networks were found with the same distribution of CD20^＋B cells;most of CXCR4^＋ cells and CD38^＋cells distributed in the cap of germinal center, and minority of these cells located in the light zone of germinal center and intermediate zone of lymphoid nodule. Conclusion There are lots of CXCR4^＋ cells and CD38^＋ cells around FDC networks, which facilitate infection and replication of HIV. The distribution of FDCs in lymph node is closely related to HIV pathogenesis and should become the main research target on HIV infection.
作者 陈欢 姜拥军 高杰
机构地区 中国医科大学附属第一医院卫生部艾滋病免疫学重点实验室 中国医科大学基础医学院神经解剖学研究室
出处 《中国医科大学学报》 CAS CSCD 北大核心 2008年第4期524-525,528,共3页 Journal of China Medical University
基金 国家自然科学基金资助项目(30400383)
关键词 淋巴结 生发中心 滤泡树突状细胞 C-X—C家族超化因子受体4 CD38 lymph node germinal center follicular dendritic cell C-X-C chemokine receptor 4 CD38
分类号 R512.91 [医药卫生—内科学]
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参考文献10

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共引文献1

同被引文献18

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中国医科大学学报
2008年 第4期

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