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肠道病毒71型及其相关疾病研究进展 被引量：32

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摘要 肠道病毒71（EV71）是一种新型肠道病毒。1969年在美国加利福尼亚州患有脑炎的婴儿粪便中首次分离到EV71。EV71感染临床上表现除了无菌性脑膜炎、急性小脑共济失调和急性松弛性瘫痪（AFP）外，还出现了大量手足口病（hand—foot—mouth disease，HFMD）。目前发现，引起HFMD这种全球性传染病的病原体除了肠道病毒柯萨奇A16（CA16）等，EV71也是其主要病原体之一，
作者 冯云 张文宏
机构地区 复旦大学附属华山医院传染科
出处 《中华传染病杂志》 CAS CSCD 北大核心 2008年第7期396-398,共3页 Chinese Journal of Infectious Diseases
关键词 肠道病毒71型 相关疾病 EV71 加利福尼亚州 无菌性脑膜炎 首次分离 手足口病 HFMD
分类号 R51 [医药卫生—内科学]
  • 相关文献

参考文献16

  • 1McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev, 2002, 26:91-107.
  • 2卫生部.卫生部通报安徽省阜阳市发生手足口病疫情的情况[EB/OL]. (2008-05-03). http://www.gov. cn/gzdt/2008-05/03/content_960290. htm.
  • 3中国疾病预防控制中心.手足口病预防控制指南(2008年版)[EB/OL](2008-05-20). http: //www. chinacdc.net.cn/ n272442/n272530/n275462/n275477/n292888/23509.html.
  • 4Hamaguchi T, Fujisawa H, Sakai K, et al. Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult. Emerg Infect Dis, 2008, 14:828- 830.
  • 5Kung CM, King CC, Lee CN, et al. Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan. J Med Virol, 2007,79 : 60-68.
  • 6Chen YC, Yu CK, Wang YF, et al. A murine oral enterovirus 71 infection model with central nervous system involvement. J Gen Virol, 2004,85:69 -77.
  • 7Liang CC, Sun MJ, Lei HY, et al. Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. J Med Virol, 2004, 74:597-603.
  • 8Chen CS, Yao YC, Lin SC, et al. Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. J Virol, 2007, 81:8996 -9003.
  • 9田波,段海生,荣一兵,周世力.肠道病毒71型分子流行病学研究进展[J].中国病毒学,2004,19(4):426-429. 被引量：90
  • 10Ooi MH, Solomon T, Podin Y, et al. Evaluation of different clinical sample types in diagnosis of human enterovirus 71- associated hand foot-and-mouth disease. J Clin Microbial, 2007, 45:1858-1866.

二级参考文献28

  • 1Chiueh T S, Huang C P, Yen C T, et al. Multiplex Reverse Transcription-semi-nested PCR for Differentiating Enterovirus 71, Coxsackievirus A16,and Polioviruses from Other Enteroviruses[J]. J Med Sci,2001, 21: 277-282.
  • 2Fujimoto T, Chikahira M, Yoshida S, et al. Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epide- miology of enterovirus 71 [J]. Microbiol Immunol, 2002;
  • 3Brown B A. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998[J]. J Virol, 1999, 73:9969-9975
  • 4McMinn P C. An overview of the evolution of enterovirus 71 and its clinical and public health significance[J]. FEMS Microbiol Rev. 2002,26: 91-107.
  • 5Ooi E E, Phoon M C, Ishak B, et al. Seroepidemiology of human enterovirus 71[J]. Emerg Infect Dis, 2002, 8: 995-997.
  • 6Lum L C S. Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis[J]. Lancet, 1998, 352: 1391.
  • 7Brown B A, Kilpatrick D R. Serotype-specific identification of enterovirus 71 by PCR[J]. J Clin Virol, 2000, 16: 107-112.
  • 8Singh S. RT-PCR, nucleotide, amino acid and phylogenetic analyses of enterovirus type 71 in Asia[J]. J Virol Methods, 2000, 88: 193-204.
  • 9Tsao K C, CHANG P Y, Ning, H C, et al. Use of molecular assay in diagnosis of hand,food and mouth disease caused by enterovirus 71 or coxsackievirus A 16 [J]. J Virol Methods, 2002, 102: 9-14.
  • 10Shih S R, Wang Y W, Chen G W, et al. Serotype-specific detection of enterovirus 71 in clinical specimens by DNA microchip array[J]. J Virol Methods, 2003, 111: 55-60.

共引文献95

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引证文献32

二级引证文献107

中华传染病杂志
2008年 第7期

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