超敏C反应蛋白、白细胞介素-6、瘦素与2型糖尿病肾病的相关性研究

The correlation of ultra-sensitive C-reactive protein,interleukin-6,Leptin levels with type 2 diabetic nephropathy

目的探讨在糖尿病肾病的发生过程中血超敏C反应蛋白(usCRP)、白细胞介素-6(IL-6)、瘦素(LEP)的变化。方法根据尿白蛋白排泄率(UAER)将123例2型糖尿病患者分为正常白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组,另选31例作为正常对照组,观察各组血中usCRP、IL-6、LEP水平并进行比较,与有关指标进行相关性分析。结果2型糖尿病各组血中usCRP、IL-6、LEP水平较正常对照组明显升高,且usCRP、IL-6、LEP水平随白蛋白尿的增加而升高。结论血usCRP和IL-6、LEP浓度增高可能是糖尿病肾病的重要危险因素;炎症反应强度与肾病的严重程度有关。

Objective To study the changes of the serum ultra-sensitive C-reactive protein,interleukin- 6 ,Leptin in different stages of diabetic nephropathy. Methods 123 patients with type 2 diabetes mellitus were divided into three groups according to their urinary albumin excretion rate（ UAER）. The levels of usCRP , IL-6 and LEP were observed, correlation analysis was also done between usCRP, IL-6, LEP and other indexes. Resuits The levels of usCRP , IL-6, LEP were significantly higher in patients with type 2 diabetic groups than that in normal controls,usCRP , IL-6 and LEP concentrations were increased with increment of UAER in patients with type 2 diabetes mellitus. Conclusion Serum us-CRP, IL-6 and LEP may play important roles in the pathogensis of diabetic nephropathy, the degree of acute-phase reaction is correlated with the severe of diabetic nephropathy.