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Smac与肿瘤 被引量：2

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摘要 Smac Smacl Second mitochondrical activator of caspase是一种新发现的线粒体蛋白,在细胞凋亡过程中起着重要作用;当细胞发生凋亡时,其与细胞色素C一起被释放进入细胞浆,在细胞色素C/Apaf-1/Caspase-9凋亡途径中促进Casepase(含半胱氨酸的天冬氨酸特异性蛋白酶)的激活。Smac通过解除凋亡抑制蛋白对Caspase-3、Caspase-7、Casepase-9的抑制作用而诱导细胞凋亡。Smac的高表达可以增加细胞对凋亡刺激信号的敏感性,这对于肿瘤的发生、发展,以及肿瘤的治疗具有重要意义。
作者 郭伟 李惠翔
机构地区 驻马店市中心医院胸外科/郑州大学基础医学院
出处 《中国实用医药》 2008年第21期192-194,共3页 China Practical Medicine
关键词 肿瘤 凋亡 SMAC Casepase
分类号 R730.2 [医药卫生—肿瘤]
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参考文献15

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同被引文献32

  • 1段文涛,龚建平.IAP家族的成员XIAPs、urvivin与肿瘤的诊断和治疗研究进展[J].山西医科大学学报,2006,37(6):654-656. 被引量：1
  • 2Clark MJ,Sterrett JJ,Carson DS. Diabetes guideline:a summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical EndoScrinologists[J]. Clinical Therapeutics,2000,22 (8):899-910.
  • 3Brownlee M. The pathobiology of diabetic complications:a unifying mechanism[J]. Diabetes, 2005,54 (6) :1615-1625.
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  • 6Winiarska K,Fraczyk T,Malinska D, et al. Melatonin attenuates diabetes-induced oxidative stress in rabbits[J]. Journal of Pineal Research, 2006,40 (2) : 168 -176.
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  • 8Hasenjager A, Gillissen B, Muller A, et al. Smac induces cytochrome e release and apoptosis independently from Bax/ Bcl-x(L) in a strictly Caspase-3-dependent manner in human carcinoma cells[J]. Oncogene, 2004,23 (26) : 4523-4535.
  • 9Gorka M, Lamparska Przybysz M, Motyl T. Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in Caspase-8-and Bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 ceils exposed to eamptothecin[J]. Cellular and Molecular Biology, 2007,52 (Suppl) :915-922.
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中国实用医药
2008年 第21期

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