应用载体构建小干扰RNA对小鼠葡聚糖硫酸钠结肠炎的影响
摘要
溃疡性结肠炎（ulcerativc colitis，UC）的病因和发病机制尚不清楚，治疗仍是临床上的一大难题。传统药物疗效欠佳，不良反应大。有研究显示，UC发病与肿瘤坏死因子（TNF）-α关系密切，使用抗TNF-α抗体有治疗作用，但维持时间短。RNA干扰（RNAi）技术有高度的特异性和有效性，不仅能抑制外源性基因而且能特异性沉默内源性基因表达￥为抗炎、抗凋亡、抗肿瘤提供了新的思路和方法。本研究将RNAi进一步运用于葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎模型上，探讨其治疗作用，以寻找治疗UC的新途径。
出处
《中华消化杂志》
CAS
CSCD
北大核心
2008年第7期492-494,共3页
Chinese Journal of Digestion
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