女贞子提取物预防四氯化碳所致小鼠急性肝损伤的实验研究

Protective effect of extract of ligustrum lucidum ait against hepatic injury induced by CCI4 in mice

目的研究女贞子提取物对小鼠四氯化碳所致小鼠急性肝损伤的保护作用。方法用0．12％的四氯化碳橄榄油溶液10ml／kg（0．2ml／20g）腹腔注射造成小鼠急性肝损伤，以血清丙氨酸氨基转移酶（SGPT）、肝组织丙氨酸氨基转移酶（LGPT）以及超氧化物歧化酶（SOD）活性为指标，观察女贞子提取物对急性肝损伤的保护作用。结果女贞子提取物对升高的SGPT、LGPT含量有降低作用，能明显增高SOD活性。结论女贞子提取物对四氯化碳所致小鼠急性肝损伤具有保护作用。

Objective To study the protective effect of extract of ligustrum lucidum ait against CCI4 - induced hepatic injury in mice. Methods Acute liver injury model in mice was made by using 0. 12% CCI4. The levels of SGPT,LGPT inserum and SOD in liver were observed. Results Compared with model control group, the levels of SGPT,LGPT of the mice treated with extract of lignstrum lucidum ait significantly decreased,while the activity of SOD increased greatly. Conclusion Extract of lignstrum lucidum ait can prevent CCI4 - induced hepatic injury.