雷贝拉唑对幽门螺杆菌阴性胃溃疡的疗效观察

Curative Effect of Rabeprazole in Treatment of Helicobacter Pylori-negative Gastric Ulcer

目的观察分析雷贝拉唑治疗幽门螺杆菌(Hp)阴性胃溃疡(GU)的临床疗效。方法收集120例Hp阴性的胃溃疡患者,随机分为两组,观察组接受雷贝拉唑治疗,而对照组接受雷尼替丁治疗。治疗4周后观察临床症状情况,并通过胃镜检查,观察溃疡愈合,并比较胃窦部炎症情况。结果经4周治疗后,发现观察组患者临床症状(如上腹部疼痛、上腹不适、嗳气)得到明显控制,溃疡愈合率明显高于对照组(P<0.05),胃窦部炎症分级也明显降低(P<0.05)。结论雷贝拉唑可有效地缓解Hp阴性GU症状,加强GU愈合,是治疗GU的一种有效方法。

Objective To observe and analyze the clinical effect of rabeprazole in the treatment of helicobacter pylori （Hp） - negative gastric ulcer（GO）. Methods Totally 120 patents with Hp - negative GO were randomly divided into two groups, which observation group was treated with rabeprazole and control group was treated with ranitidine. Clinical effect and inflammation changes in gastric antrum were analyzed 4 weeks after treatment. Results Rabeprazole significantly improved clinical symptoms of epigastric pain, epigastric discomfort, and belch （P〈 0.05） and markedly enhanced GU healing （P〈 0.05）, inflammation in gastric antrum was also significantly improved （P〈 0.05） in observation group as compared with control group. Conclusion Rabeprazole is effective in treating Hp- negative GU and enhancing ulcer healing.