前炎症因子在脊髓型颈椎病发病中的作用

Effect of Proinflammatory Cytokines at Early Stage of Cervical Spondylotic Myelopathy

目的探讨前炎症因子在脊髓型颈椎病发病的早期变化,探讨前炎症因子与颈椎间盘早期退变的关系。方法收治的20例脊髓型颈椎病患者,完整摘除并且取出的32个颈椎节段的椎间盘及其髓核组织,作为实验组的病例来源。选择3具新鲜尸体中15个颈部椎间盘组织,作为对照组。观察TNF-α,IL-1β,IL-6的表达情况。结果实验组TNF-α,IL-1β,IL-6阳性表达率和IOD值均显著高于对照组(P<0.01)。结论突出的颈椎间盘可产生TNF-α,IL-1β,IL-6阳性细胞,提示这些细胞因子在颈椎椎间盘早期退变中发挥作用。

Objective To discuss the expression change of proinflammatory cytokines at the early stage of cervical spondylotic myelopathy and the relationship with early disc degeneration. Methods Thirty - two cervical discs from 20 patients with cervical spondylotic myelopathy were collected and studied as experiment group. Fifteen cervical discs from fresh cadavers with death time less than 24 hours were also collected and studied as control group..The expression of TNF-α,IL-1β, and IL- 6 was tested by immunohistochemistry. Results The positive expression rates of TNF-α,IL-1β, and IL - 6 and the IOD value in the experiment group were significantly higher than those of the control group （P〈 0.01）. Conclusion The tissues of herniated disc can produce TNF-α,IL-1β, and IL - 6 cytokines . These cytokines may play a role in the degeneration of cervical disc.