术后放疗联合同步化疗治疗脑恶性胶质瘤疗效观察

Postoperative Concurrent Radiotherapy and Chemotherapy for Malignant Cerebral Glioma

目的回顾性分析脑恶性胶质瘤术后放化疗联合治疗临床疗效。方法对资料完整的126例脑恶性胶质瘤患者进行回顾性研究,分为单纯放疗组(64例)、给予术后单纯放疗和放化疗联合组(62例)、给予放疗后替尼泊苷联合司莫司汀化疗,对组间生存差异进行比较。结果成人恶性胶质瘤术后单纯放疗组1、3、5年生存率分别为64.06%、31.25%、15.63%;术后同步放化疗组1、3、5年生存率分别为80.65%、50%、30.65%。同步放化疗组生存率明显优于单纯放疗组(P<0.05)。结论脑恶性胶质瘤术后放化疗联合治疗有较好疗效,毒副反应可以耐受,值得临床推广。

Objective To retrospectively analyze and evaluate the outcome of malignant cerebral glioma treated by chemotherapy plus radiotherapy. Methods A total of 126 patients with malignant cerebral glioma were retrospectively studied. Sixty- four patients in the radiotherapy group were irradiated with DT54 - 60 Gy, 62 patfents in the chemotherapy plus radiotherapy group were given chemotherapy （VM - 26 and Me - CCNU） after exposure to DT 20 Gy. The 1 -, 3 - and 5 - year survival rates of these patients were compared. Results The 1 -, 3 -, and 5 - year survival rates of the radiotherapy group were 64.06%, 31.25%, and 15.63% respectively, while the 1 -, 3-, and 5 -year survival rates of the chemotherapy plus radiotherapy group were 80. 65 %, 50 %, and 30.65 % respectively （P 〈 0.05） . Conclusion Combination of chemotherapy and radiotherapy is effective and welt- tolerated in the treatment of malignant cerebral glioma.