中西医结合治疗妊娠期肝内胆汁淤积症疗效分析

Therapeutic Effect of Combined Western and Chinese Medicine on Intrahepatic Cholestasis in Pregnancy

目的:评估茵陈蒿汤和熊去氧胆酸两药合用与单用熊去氧胆酸治疗妊娠期肝内胆汁淤积症(ICP)及改善围生儿预后的疗效。方法:将60例ICP住院患者随机分为两组。A组采用茵陈蒿汤与熊去氧胆酸合用治疗,B组单用熊去氧胆酸治疗。治疗3周后观察瘙痒症状,血清生化指标(甘胆酸、胆红素、转氨酶),分娩后比较两组围生儿预后情况。结果:两组治疗后瘙痒症状、血清甘胆酸、胆红素、转氨酶A组较B组疗效明显改善(P<0.05),但治疗后两组间围生儿预后差异无显著性(P>0.05)。结论:茵陈蒿汤与熊去氧胆酸合用比单用熊去氧胆酸治疗ICP疗效更显著,而价廉、安全,患者易接受,适宜推广。

Objective：To evaluate the therapeutic effect of Yinchenghao decoction （YCHD） and Ursodeoxycholic acid tablets（UAT） in treating intrahepatic cholestasis of pregnancy（ICP） and improving prognosis of perinatal newborn babies.Methods： Sixty in-patients of ICP were randomly divided into two groups： group A treated with YCHD and UAT,group B treated with UAT.The symptoms of itching,serum biochemical indexes（including glycocholic acid,bilirubin and transaminase） were observed after 3 weeks of treatment,and the progosis of perinatal newborn babies between the two groups was compared after baby delivery.Results： after treatment,the symptoms of itching,serum levels of glycocholic acid,bilirubin and transaminase were improved significantly（P〈0.05） in both groups.There was no significant difference in the prognosis of newborn between the two groups（P〉0.05）.Conclusion： The combination of YCHD and UAT can effectively treat ICP.It is a cheap and feasible way for spreading.