清风藤化学成分的研究(英文)

Chemical constituents of Sinomenium acutum

目的研究药用植物清风藤Sinomenium acutum的化学成分。方法清风藤分离除去青藤碱后的苯母液经过反复硅胶柱色谱，以氯仿、氯仿-甲醇、石油醚．丙酮洗脱分离其中残余的其他生物碱类成分。通过波谱分析方法和X-射线衍射分析法确定化合物结构。结果从清风藤除去青藤碱后的母液中分离出4个微量生物碱，分别鉴定为：四氢表小檗碱tetrahydroepiberberine（I）、紫堇碱eheilanthifoline（Ⅱ）、8-氧四氢小檗碱8-oxocanadine（Ⅲ）、8-氧四氢巴马丁8-oxotetrahydropalmatine（Ⅳ）。结论化合物Ⅱ～Ⅳ为首次从该植物中分离得到。

Aim To study the chemical constituents of Sinomenium acutum. Methods The mother liquid benzene, after the extraction of sinomenine from Sinomenium acutum, was subjected to repeated chromatography on a silica gel column and eluted with CHCl3, CHCl3/CH3OH and petroleum ether/acetone. All the isolated compounds were identified on the basis of spectral analysis and X-ray diffraction analysis. Results Four compounds were obtained and their structures were cha-racterized as tetrahydroepiberberine （ I ）, cheilanthifoline （ Ⅱ ）, 8-oxocanadine （Ⅲ ）, 8-oxotetrahydropalmatine（ Ⅳ ）, respectively. Conclusion Compounds Ⅱ - Ⅳ were isolated from Sinomenium acutum for the first time.