文拉法辛与阿普唑仑治疗广泛性焦虑的比较

Comparative study of venlafaxine and alprazolam in generalized anxiety disorder

目的:比较文拉法辛与阿普唑仑治疗广泛性焦虑的临床疗效及不良反应。方法:采用随机分组的方法,对66例广泛性焦虑者随机分为文拉法辛组(33例)和阿普唑仑组(33例),疗程6周。用焦虑自评量表(SAS),Hamilton焦虑量表(HAMA)和治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:治疗第2周末两组HAMA总分与治疗前相比均有明显下降(P<0.05);文拉法辛组SAS总分与治疗前相比有明显下降(P<0.05);6周后两组SAS及HAMA评分均显著下降(P均<0.01)。不良反应文拉法辛组较阿普唑仑组少而轻。结论:文拉法辛治疗广泛性焦虑安全、有效,不良反应少。

Objective：To compare the clinical efficacy and side effects between venlafaxine and alprzolam in the treatment of generalized anxiety disorder. Methods： 66 patients with generalized anxiety disorder swere randomly assigned to venlafaxine group （ n= 33 ） and alprazolam group （ n = 33 ） and followed by the medication for 6 weeks. The clinical effects and side effects were tested with Himilton depressive scale （HAMA）, self-rating anxiety scale （SAS） and treatment emergent symptom scale （TESS）. Results： The scores of HAMA and SAS in both venlafaxine and alprazolanl group reduced significantly at the end of 2nd week after treatment（ P 〈 0.05 ）, and the same findings were observed between the two groups after six weeks of medication （ P 〈 0.01 ）, but the side effects were less in venlafaxine group than alprzolanl group. Conclusion ： Venlafaxine is effective in treating generalized anxiety disorder with safety and mild side effects.