小檗碱治疗沙眼衣原体致非淋菌性尿道(宫颈)炎的临床观察

Clinical Observation of Berberine in Treatment of Non-Gonococcal Urethritis and Cervicitis Due to Chlamydia Trachomatis

目的:观察小檗碱治疗沙眼衣原体性非淋茵性尿道(宫颈)炎的疗效与安全性。方法:86例非淋菌性尿道(宫颈)炎患者分成两组:治疗组(小檗碱)44例,口服小檗碱0.4g,3次/天,连用14天;对照组(多西环素)42例,口服多西环素0.1g,2次/天,连用14天,观察疗效与安全性。结果:治疗组临床总有效率、细菌清除率、不良反应率依次为65.9%,65.9%,18.2%.对照组依次为73.8%,73.8%,14.3%,无统计学差异。结论:小檗碱治疗沙眼衣原体致非淋菌性尿道(宫颈)炎安全、有效。

Objective ：To observation the efficacy and safety, of berberine in treating non -gonoeoeeal urethritis and cervicitis due to chlamydia trachomatis. Methods ：86 patients with non -gonoeoccal urethritis and cervicitis were randomized into treatment Group （n =44）and control Group（n =42）. Treatment group was treated oral berberine 0. 4g,tid for 14 days. Control group was treated oral doxycyeline 0. 1g, bid for 14 days. The efficacy and safety of all patients were observed before and after the treatment. Results ： The overall efficacy rates of berberine and doxycycline were 65.9% and 73.8% ,Bacteria elimination rates were 65.9% and 73.8%, and the side effect rates wore i8.2% and 14. 3% respectively. No significant differences were observed between the two groups. Conclusion：Berberine is effective and safe in treating non - gonoeoecal ttrethritis and cervicitis due to chlamydia trachomatis.