中药对肺纤维化大鼠肺组织病理改变的作用

Effect of Chinese Herb on Lung Tissue Pathologic Change in Bleomycin-Induced Pulmonary Fibrosis in Rat

目的:探讨中药对肺纤维化大鼠肺组织不同时期病理改变的影响。方法:36只W istar大鼠随机分为正常对照组、模型组、中药组,分别于14、28天观察肺组织病理改变中药对它们的影响。结果:①模型组急性期肺组织肺泡炎症表现显著,巨噬细胞活化明显,慢性期以肺间质纤维母细胞增生,纤维化形成较明显。②中药组肺组织急性期炎症反应较模型组减弱(P<0.01),巨噬细胞活化减弱;纤维化程度明显低于模型组(P<0.05)结论:肺纤维化早期巨噬细胞活化明显,以炎症反应为主,晚期以纤维化形成为主。中药通过减弱巨噬细胞的活性从而抑制肺纤维化发展。

Objective：To investigate the pathologic change of lung tissue in bleomycin -induced pulmonary fibrosis in rat and the effect of Chinese herb on it. Methods ：36 Wistar rats were divided into three groups randomly： control group , model group and Chinese herb treat group. Observe the lung tissue pathologic change and the effect of Chinese herb on them on 14 and 28 day respectively. Results ：①The alveoli inflammation and macrophage active of model group were increased obviously during the acute phase and the fibres; were the major react during chronic phase. ② The lung tissue inflammation of Chinese herb group were milder than model group （ P 〈 0.01 ）, lung fibrosis also milder（ P 〈 0.05 ） than model group. Conclusion ：The pathologic change were alveoli inflammation in the acute phase, and the major react in the chronic phase were fibrosis. Macrophnge play an important role in the lung fibrosis. Chinese herb inhibits pulmonary fibross through reduce the activation of macrophage.