南葶苈子不同炮制品药效学与急性毒性实验研究

Experimental Research on Pharmacology and Acute Toxicology of Descurainia Sophia(L.) Webb ex Prantl Processed

目的:观察研究南葶苈子不同炮制品的镇咳、祛痰、利尿作用和急性毒性。方法:采用小鼠"氨水引咳"法、"酚红排泌"法、大鼠"代谢笼"法观察不同炮制品在镇咳、祛痰、利尿方面的作用,测定小鼠的半数致死量和最大耐受量来考察其急性毒性。结果:南葶苈子不同炮制品能明显延长小鼠咳嗽潜伏期,减少咳嗽次数,促进酚红排泌,增加大鼠排尿量,LD50未能测出,小鼠最大耐受量30g生药/kg,为成人临床常用剂量的200倍。结论:南葶苈子不同炮制品有明显的止咳、祛痰、利尿作用,其急性毒性较低。

Objective：To study antitussive, expectorant, diuretic effects and acute toxicity of Descurainia Sophia（ L. ） Webb ex Prantl processed. Methods ： Antitussive experiments in mice with cough induced by ammonia water. Expectorant experiments with phenol red excretion method in mice. Metabolic cage method of rats was adopted to be engaged in diuresis experiments. To observe acute toxicity by measure the 50% lethal dose （LDso） and the maximum tolerance dose （MTD） in mice. Results： Descurainia Sophia （ L. ） Webb ex Pranfl Processed may lead to elongation of cough - induced patent period, reduction of cough times and increasing of phenol red secretion Volume in mice , significantly increase the urinary output in rats , the 50% lethal dose （ LD50） can not be measured, the crude drug maximum tolerance dose of mice was 30g/kg, 200 times of that in human. Conclusion ：Descurainia Sophia （L.） Webb ex Prantl Processed were effective on relieving cough, dispelling phlegm and diuresis obviously. , and the acute toxicity was low.