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支气管哮喘患者血清IL-13、IFN-γ水平变化及意义 被引量：5

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摘要 目的观察轻度持续和中度持续支气管哮喘(简称哮喘)患者外周血白细胞介素13(IL-13)与干扰素γ(IFN-γ)的变化,探讨IL-13和IFN-γ在哮喘发病机制中的可能作用及其与哮喘病情严重程度的相关性。方法收集轻度持续哮喘患者30例,中度持续哮喘患者28例,并设立健康对照组30例。采用酶联免疫吸附试验(ELIsA)测定两哮喘组和健康对照组外周血IL-13和INF-γ的水平。结果与健康对照组比较,轻度持续哮喘患者外周血IL-13水平显著增高,INF-γ水平则明显降低;中度持续哮喘患者外周血IL-13水平较轻度持续患者进一步升高,而INF-γ水平仍显著低于轻度持续患者。结论IL-13和INF-γ参与了哮喘发病,INF-γ/IL-13失衡是其机制之一,两细胞因子失衡水平与哮喘严重程度存在相关性。可作为病情判断的参考指标。
作者 洪旭初 徐顺贵 叶玲
机构地区 福建中医学院附属人民医院
出处 《福建中医药》 2008年第3期1-2,共2页 Fujian Journal of Traditional Chinese Medicine
基金 福建省教育厅科研项目(JB05157)
关键词 支气管哮喘 白细胞介素13 干扰素Γ
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献10

  • 1TRUYEN E,COTEUR L,DILISSEN E,et al. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients[J]. Thorax,2006,61 (3): 202-208.
  • 2中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量：3565
  • 3徐萌,李建强.白介素-13和哮喘发病的研究进展[J].国际呼吸杂志,2007,27(9):703-705. 被引量：8
  • 4HE1NZMANN A,MAO X Q,AKA1WA M,et al. Genetic variants of IL-13 signalling and human asthma and atopy[J]. Hum Mol Genet, 2000,9 (4) :549-559.
  • 5KUNAR P K,HERBERT C,YANG M,et al. Role of interleukin- 13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma[J ]. Clin Exp Allergy, 2002,32 (7) : 1104 -1111.
  • 6TAKAM1 K,TAKUWA N,OKAZAK1 H,et al. Interferon-γ Inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells :upregulation of p27 (kipl) cydin-dependent kinase inhibiter[J]. Am J Respir Cell Mol Biol, 2002~ 26 (2) : 231-238.
  • 7LIU C T,WANG Z L. edited in chief Airway Inflammatory Diseases [ M]. Beijing : People's Medical Publishing House,2004 : 37.
  • 8王国良,赵国华,王永平,孟君.哮喘患儿T_H细胞亚群及相关因子的分析[J].中国儿童保健杂志,2001,9(6):426-427. 被引量：13
  • 9李刚.哮喘患者血清TNF-α、IL-13、IgE水平变化及意义[J].山东医药,2007,47(20):57-58. 被引量：13
  • 10HEATON T,ROWE J,TUMER S,et al. An immunoepidemiological approach to asthma:identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children[J]. Lancet,2005,365(9454) :142-149.

二级参考文献14

  • 1[1]Mosmann TR, Cherwinski H, Bond Mw, et al. Two types of murine helper T cell clone Definition accrding to profiles of lymphokine aclivilives and secreted protein.s [J]. J Immunol, 1986,136: 2348-2357.
  • 2[2]Maggi E,Biswas P, Del-prete G, et al. Accumulation of TH2-Like the conjunctive ofpatients with conjunctivitis [J]. Immunol,1991, 146:1169-1174.
  • 3Donaldson DD, Whitters MJ, Fitz LJ, et al. The murine IL- 13receptor alpha2: molecular cloning, characterization, and comparison with murine IL-13 receptor alphal. J Immunol, 1998, 16:2317-2324.
  • 4Kabesch M, Schedel M, Carrd. IL-4/IL-13 Pathway genetic strongly influence serum IgE Ievels and childhood asthma. Allergy Clin Immunol, 2006,117 : 269-274.
  • 5Ly Np, Li Y, Sredl D1, et al. Elevated allergen-induced IL-13 secretion predicts IgE elevation in children age 2-5 year. Clin Immunol, 2005,25 : 314-320.
  • 6Li Y, martin LD, Minnicozzi M, et al. Enhanced expression of mucin denes in a guinea pig model of allergic asthma. Am J Respir Cell Mol Biol,2001,25:644-651.
  • 7Yang M, Hgan SP, Henry PJ, et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol, 2001,25 : 522-530.
  • 8Aliman MZ, Piazza FM, selby DM, et al. Muc-5/5al muein messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol,2002, 22 : 253-260.
  • 9Cohn L. Mucus in chronic airway diseases: sorting out the sticky details. Clin Invest, 2006,116 : 306-308.
  • 10Abra JH,Finn PW, Milton DK, et al. Infant home endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhood. Allergy Clin Immunol,2005,116:431-437.

共引文献3594

同被引文献47

引证文献5

二级引证文献25

福建中医药
2008年 第3期

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