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树枝状聚合物作为生物药物分子载体的研究 被引量：3

Advances of dendri mers as vehicle of biological drug molecules
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摘要 此文主要综述了树枝状聚合物作为生物药物分子如基因、蛋白质载体的研究及其特性、种类、口服吸收及毒性。
作者 时银萍 郭红霞 赖丽芳 王凤山
机构地区 山东大学药学院药物制剂研究所
出处 《中国生化药物杂志》 CAS CSCD 2008年第4期283-286,共4页 Chinese Journal of Biochemical Pharmaceutics
关键词 树枝状聚合物 生物药物分子载体 口服吸收 毒性
分类号 R944.9 [医药卫生—药剂学] R965 [医药卫生—药理学]
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参考文献27

  • 1Hayes P Y, Ross B P, Thomas B G, et al. Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin [ J ]. Bioorg Med Chem, 2006,14 : 143-152.
  • 2Shah D S, Sakthivel T, Toth I, et al. DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers [ J ]. Int J Pharm, 2000,208 : 41-48.
  • 3Sakthivel T, Florence A T. Dendrimers and dendrons : facets of pharmaceutical nanotechnology[ J ]. Drug Delivery Technol, 2003,3 (50) : 52- 56.
  • 4Vogtle L, Michael F, Eric E S. In vitro and in vivo evaluation of a melamine dendrlmer as a vehicle for drug delivery [ J ]. Int J Pharm, 2004,251 : 129-132.
  • 5Frechet, Woller E K. Altering the strength of lectin binding interactions and controlling the amount of lectin clustering using mannose/hydroxyl- functionalized Dendrlmers[J]. J Am Chem Soc,2003,125:8820-8826.
  • 6Florence A T, Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems : evolving vistas [ J ~. Adv Drug Deliv Rev, 2001,50 : $69-$89.
  • 7El-Sayed M, Ginski M, Rhodes C, et al. Transepithelial transport of poly (amidoamine) dcndrimcrs across Caco-2 cell monolaycrs [ J ]. J Controlled Release.2002.81 : 355-365.
  • 8Luo Y, Prestwich G D. Cancer-targeted polymeric drugs [ J ]. Curr Cancer Drug Targets, 2002,2 : 209-226.
  • 9扈金萍,刘永利,张锦楠.纳米生物材料——聚酰胺-胺树状大分子[J].首都医科大学学报,2002,23(3):284-286. 被引量：1
  • 10Roessler B J, Bielinska A U, Janczak K, et al. Substituted β-Cyclodex-trins interact with PAMAM Dendrimer-DNA complexes and modify tTransfection efficiency[ J]. Biochem Biophys Res Commun, 2001,283 : 124-129.

二级参考文献33

  • 1MUMPER RJ, KLAKAMP SL. Advanced Gene Delivery[ M]. Amsterdam: Harwood Academic Publishers, 1999. 143-173.
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  • 6Eichman JD,Bielinska AU,Kukowska-Latallo JF,et al.The use of PAMAM dendrimers in the efficient transfer of genetic material into cells [J].PSTT,2000,3 (7):232-245.
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  • 8Witvrouw M,Fikkert V,Pluymers W,et al.Polyanionic (i.e.,polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle [J].Mol Pharmacol,2000,58 (5):1100-1108.
  • 9Arkas M,Tsiourvas D,Paleos CM.Functional dendrimeric "nanosponges" for the removal of polycyclic aromatic hydrocarbons from water[J].Chem Mater,2003,15 (14):2844-2847.
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共引文献5

同被引文献55

引证文献3

二级引证文献11

中国生化药物杂志
2008年 第4期

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