完全雄激素阻断治疗晚期前列腺癌的疗效评估

The evaluation on the efficacy of combined androgen blockade for metastatic prostate cancer

目的评估全雄激素阻断治疗晚期前列腺癌是否较传统治疗更为有效。方法对109例晚期前列腺癌患者的生存情况进行研究。按照治疗方法不同分两组，采用全雄激素阻断治疗为治疗组，采用纯睾丸去势治疗为对照组。比较两组在无进展生存时间和生存时间上是否存在差异。结果治疗组与对照组在无进展生存时间上的差异有统计学意义（P〈0．05），两者在生存时间上的差异无统计学意义（P〉0．05）。结论尽管全雄激素能延缓病情进展，但其阻断治疗与传统睾丸去势治疗相比，并不能改善晚期前列腺癌的生存。

Objective To evaluate combined androgen blockade（CAB） has a better efficacy than simple castration in the treatment of metastatic prostate cancer, Methods The data of 109 cases of metastatic prostate cancer were prospectively studied, They were classified into two groups, one group which were treated by CAB and the other one by castration, The differences between the two groups in progression - free survival and overall survival were compared, Results There was a significant difference in progression -free survival time, but the difference in overall survival time had no statistical significance, Conclusion Although delaying the progression of metastatic prostate cancer, CAB may not further improve the survival when compared to traditional castration.