微波辐射一步法合成富马酸单甲酯的研究

Synthesis of Monomethyl Fumarate by Microwave Radiation on One-Step Method

报道了以顺丁烯二酸酐和甲醇为原料,用微波辐射一步合成富马酸单甲酯的方法.其最佳反应条件为:微波辐射功率480 W,催化剂磷酸用量为3.0 mL,氯化铝用量为2.0 g,醇酐物质的量比为11∶,微波辐射时间12 min.结果表明,此法反应时间短,产率达92.3%.

Monomethyl fumarate is synthesized by esterification of maleic anhydride and methanol under microwave radiation on one-step method. The optimal conditions are as follows： power of microwave radiation 480 W, amount of catalyst H3PO4 used 3.0 mL, AlCl3 used 2.0 g, molar ratio of alcohol to anhydride 1：1, microwave radiation time 12 min. It is found out that, under the optimal conditions, the yield of the product reaches 92.3 %.