老年人高尿酸血症与相关疾病的探讨

The Exploration on Hyperuricemia and its Related Diseases of the Aged

目的:了解老年人(≥60岁)发生高尿酸血症的情况,探讨老年高尿酸血症与相关疾病的关系。方法:以1998年1月至2006年10月在我院住院的老年人为研究对象,采用酶学测定血尿酸(SUA),以SUA大于420mmol/l为界限,比较分析高尿酸血症组与尿酸正常组的临床资料。结果:血尿酸增高病人的比例为18.2%(178:980)。尿酸增高组的男女比例为164:14,随着各年龄组的年龄的增大,血尿酸、血尿素氮、血肌酐、血清胆固醇、甘油三酯、餐后二小时血糖、体重指数水平明显升高。与尿素正常组相比,高尿酸血症组的高血压、肾功能不全、痛风性关节炎、肥胖症、脂肪肝、糖耐量低减的发生率明显增高。结论:老年高尿酸血症与多种心血管和代谢性疾病相关。

Objective：To learn the situation of occurrence of hyperuficemia among the aged （≥60） and to explore the relation between hyperuricemia and its related diseases. Methods： To compare and analyze the clinical data both of Group of hyperuricemia and Group of normal uric acid, taking the aged patients in our hospital from Jan. 1998 to Oct. 2006 as research objects, with enzymology measuring on serum uric acid（SUA） ; and taking ≥420mmol/l as cut - off value. Results： The rate of serum uric acid increase was 18.2% （ 178： 980）. The proportion of male and female in Group of uric acid increase was 164： 14. With age increase of the groups, parameters increased evidently, such as serum uric acid, blood urea nitrogen, serum creatinine, serum cholesterol, triglyceride, blood glucose two hours after meals, body mass index. Comparing with Group of normal blood urea, the prevalence rate of hyperuricemia related diseases of Group of hyperuricemia increased obviously; including high blood pressure, renal dysfunction, gouty arthritis, adiposis, fat liver, impaired glucose tolerance. Conclusion： Hyperuricemia of the aged is related to many cardiovascular diseases as well as metabolic diseases.