丹栀逍遥散加味治疗卒中后抑郁的疗效观察

Clinical observation of modified Danzhi Xiaoyao powder in treating post-stroke depression

[目的]观察丹栀逍遥散加味治疗卒中后抑郁的疗效。[方法]108例患者按数字表法随机分为3组,每组36例,3组均接受常规药物治疗,联合组用丹栀逍遥散加味和百优解,百优解组和丹栀逍遥散加味组分别单用百优解和丹栀逍遥散加味;于治疗前和治疗后4、12周,采用汉密尔顿抑郁量表(HAMD)、简易智能状态量表(MMSE)、神经功能缺损评分量表(SSS,用改良爱丁堡斯堪的那维亚评分)和Barthel指数(BI)评定患者的认知和神经功能状况。[结果]3组HAMD和SSS评分治疗后均较治疗前显著下降(P<0.01);而3组治疗后的MMSE和BI均较治疗前显著升高(P<0.05),联合组HAMD评分下降和BI增高比另两组更明显(P<0.05)。[结论]丹栀逍遥散加味对卒中后抑郁有良好的治疗作用,与百优解合用有协同效应。

[Objective] To observe the curative effect of modified Danzhi Xiaoyao powder in treating patients with post-stroke depression. [Methods] The patients with post-stroke depression were randomly divided into three groups： modified Danzhi Xiaoyao powder group, fluoxetine and the combined group. All patients were treated with routine medicine also. The neurological and cognitive function determined with HAMD scale, MMSE scale , SSS scale and Barthel index （BI） before the treatment and at 4 and 12 weeks after treatment was evaluated. [Results] The AMD score and SSS score was significantly decreased （P〈0.01） while MMSE score and BI score was significantly increased （P〈0.05） after treatment of three groups. The decrease of HAMD score and increase of BI score in the combined group was more significant than those in the other two groups respectively （P〈0.05）. [Conclusion] Modified Danzhi Xiaoyao powder is effective in treating patients with post-stroke depression and shows synergism with fluoxetine.