山莨菪碱慢性给药对自发性高血压大鼠主动脉功能及形态的影响

Influence of anisodamine chronic administration on the vascular function and morphology spontaneously hypertensive rats

目的观察山莨菪碱慢性给药对自发性高血压（SHR）大鼠血管功能及血管形态学方面的影响。方法采用SHR大鼠慢性腹腔注射山莨菪碱，10周后急性处死，采用灌注取材法获取腹主动脉，显微镜下观察主动脉的形态学改变。采用离体主动脉环灌流技术，观察山莨菪碱对血管功能的影响。结果生理状态下，长期给予SHR大鼠山莨菪碱，可使高血压大鼠血管内皮及平滑肌舒张功能显著改善；山莨菪碱慢性用药可有效抑制SHR大鼠腹主动脉瘤形成，使血管形态结构发生良性改变。结论慢性山莨菪碱给药，可使SHR大鼠血管内皮及平滑肌功能改善，血管形态结构发生良性改变，提示山莨菪碱具有内皮及平滑肌保护作用。

Objective To investigate the influence of Anisodamine chronic administration on the vascular function and morphology of SHR. Methods The SHR were injected by chronic abdominal Anisodamine; Then the SHR were sacrificed after ten weeks. The abdominal aorta were obtained after perfusion and the changes of aorta morphology were observed under a microscope. The influence of Anisodamine on the vasculovr funtion was investigated by the rat＇s aorta tings perfusion. Results In the physiological state, given SHR long-term Anisodamine, the vascular endothelial and smooth muscle relaxation will significantly improve; Anisodamine chronic adminstration can inhibit the formation of aortic aneurysm and change a benign vascular structure. Conclusion Anisodamine chronic adminstration will improve the vascular endothelial and smooth muscle relaxation, and change a benign vascular structure, Anisodamine has a protective effect on endothelial and smooth muscle.