乳腺癌组织中COX-2、VECF—C表达与淋巴转移的相关性研究

Relationship between expressions of COX-2, VEGF-C in breast cancer and lymphatic metastasis

目的探讨COX-2、VEGF-C在人乳腺癌组织中的表达及其与淋巴转移之间的关系。方法运用免疫组织化学SABC法检测COX-2和VEGF—C在乳腺癌组织中的表达情况。结果60例乳腺癌组织中COX-2和VEGF-C的表达阳性率分别为66．7％和60．0％，且二者表达呈正相关（r=0．429，P〈0．05）。COX-2阳性、VEGF-C阳性组淋巴转移的发生率（80．0％）明显高于COX-2阴性、VEGF-C阴性组（21．4％；P〈0．05）。结论COX-2、VEGF-C在乳腺癌组织中呈过表达，呈正相关关系，且与乳腺癌的淋巴转移关系密切，COX-2表达上调可能促使VEGF-C的过表达，诱导肿瘤淋巴管的生成，从而导致乳腺癌细胞淋巴转移的发生。

Objective To detect the expressions of COX-2 and VEGF-C in breast cancer and to explore the relationship between their expressions and lymphatic metastasis. Methods Immunohistochemical staining （SABC） was used to detect the expressions of COX-2 and VEGF-C proteins in 60 cases of breast cancer. Results The positive rate of COX-2 and VEGF-C in breast cancer were 66. 7% and 60. 0%, and the expression of COX-2 was positively correlated with VEGF-C （ r = 0. 429, P 〈 0.05）. COX-2 and VEGF-C expressions were positively correlated with lymphatic metastasis （ P 〈 0. 05 ）. The lymphatic metastasis rate in the positive group of COX-2 and VEGF-C were higher than that in the negative group of COX-2 and VEGF-C. Conclusion Over expression of COX-2 and VEGF-C were observed in breast cancer, and closely related to lymphatic metastasis. COX-2 has positive correlation with VEGF-C and was correlated with lymphatic metastasis of breast cancer. COX-2 may promote the over expression of VEGF-C in tumor cells and cause lymphatic metastasis.