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HER-2在乳腺癌中的研究进展 被引量：2

Progression of HER-2 in breast cancer
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摘要 HER-2／neu基因又称c—erbB-2或erbB-2基因，是1985年确认的v—erbB-2相关的原癌基因。自从HER-2被发现与乳腺癌患者的预后不良密切相关以来，此方面的研究越来越多。现将乳腺癌中HER-2（HER-2／neu）相关知识综述如下。 The HER-2/neu gene, also named e-erbB-2 or erbB-2, is proto-oneogene of v-erbB-2 which was firstly discovered in 1985. Many studies have been reported since that amplification of the HER-2 gene in breast tumors is associated with poor prognosis was recognized. The relevant knowledge of HER-2/neu gene is summarized in this article.
作者 单涛 盛薇 李萌 王虎霞
机构地区 西安交通大学医学院第一附属医院普外科
出处 《国际外科学杂志》 2008年第8期556-558,共3页 International Journal of Surgery
关键词 乳腺癌 HER-2 临床研究 治疗方法 breast tumour HER-2
分类号 R737.9 [医药卫生—肿瘤] R737.9 [医药卫生—肿瘤]
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参考文献12

  • 1Zhou B, Hung M. Dysregulation of cellular signaling byHER-2/ neu in breast cancer[J]. Semin Oncol, 2003, 30(5) :38-48.
  • 2王跃华,王全红,李丽,肖彦增,殷卫东,杨宣琴,王丽霞,王晋芬.乳腺癌Her-2基因检测方法对比[J].临床与实验病理学杂志,2007,23(2):225-226. 被引量：11
  • 3Ariga R, Zarif A, Korasick J, et al. Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma[J]. Breast J, 2005, 11 (4) :278-280.
  • 4Tokatli F, Altaner S, Uzal C, et al. Association of HER-2/neu over expression With the number of involved axillary lymph nodes in hormone receptor positive breast cancer patients [ J ]. Exp Oncol, 2005, 27(2) :145-149.
  • 5Climent MA, Segui MA, Peiro G, et al. Prognostic value of HER2/neu and p53 expression in node 2 positive breast cancer HER2/neu effect on adjuvant tamoxifen treatment [ J ]. Breast, 2001, 10(1) :67-77.
  • 6Learn PA, Yehi T, Nuttm M, et al. HER-2 expressing as a predictor of response to neoadjuvant docetaxel in patient with operable breast carcinoma[ J]. Cancer, 2005, 103 ( 11 ) :2252-2260.
  • 7Gago FE, Fanelli MA, Ciocca DR, et al. Co-expression of steroidhormone receptors ( estrogen receptor and/or progesterone receptors) and Her2/neu (c-erbB-2) in breast cancer: clinical outcome following tamoxifen-based adjuvant therapy[ J]. J Steroid Biochem Mol Biol, 2006, 98 (1) :36-40.
  • 8Laurentiis M, Arpino G, Massarelli E, et al. A meta-analysison the interaction between Her-2 expression and responseto endocrine treatment in advanced breast cancer[J]. Clin Cancer Res, 2005, 11(3) :4741-4748.
  • 9Papaldo P, Fabi A, Ferretti G, a al. Phase Ⅱ study on metastatic breast cancer patients treated with weekly vinorelbine with or without trastuzumab according to HER2 expression: changing the natural history of HER2-positive disease [ J ]. Ann Oncol, 2006, 17 (4) :630-636.
  • 10Waintraub SE. Phase Ⅱ trial to study the efficacy and toxicity of combined docetaxel( D), carboplatin( C), t/_trastuzumab(T) administered weekly (W) in patients ( pts ) with HE R2/neu t/_ metastatic breast cancer ( MBC ) [ R ]. USA : ASCO, 2005. abstract 832.

二级参考文献5

  • 1曾瑄,赵大春,周炜洵,武莎斐,梁智勇,刘彤华.荧光原位杂交检测乳腺癌HER2基因状态[J].中华病理学杂志,2005,34(11):701-705. 被引量：65
  • 2虞有智,姜宝玉,陈定宝,沈丹华.显色原位杂交技术在乳腺癌HER-2/neu原癌基因检测上的应用及意义[J].中华病理学杂志,2006,35(1):51-52. 被引量：9
  • 3Swiatoniowski G, Dabrowska M. Klaiewski T, et al. Erb-2 overexpression in breast cancer[J].Ginekol Pol.2003. 74(4): 332-338.
  • 4Hammock L, Lewis M, Phillips C, et al. Strong HER-2/neu protein overexpression by immunohistoehemistry often does not predict oncogene amplification by fluorescence in situ hybridizalion [J]. Hum Pathol, 2005,36: 1043-1047.
  • 5Gupta D, Middlelon L P, Whitaker M J, et al. Comparison of fluorescence and chromogenic in situ hybridization for detection of HER-2/neu oncogene in breast caneer [J]. Am J Clin Pathol, 2003. 119: 381-387.

共引文献10

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国际外科学杂志
2008年 第8期

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