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环氧化酶-2与乳腺癌关系的研究现状及进展

Relationship between COX-2 and breast cancer
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摘要 环氧化酶-2(cycloxygenase-2,COX-2)在人类多种肿瘤的发生发展过程中起着重要作用,其在乳腺癌中也存在着过度表达。因此,进一步深入研究COX-2与乳腺癌的关系,开发理想的COX-2抑制剂,以期开辟乳腺癌防治的一条新途径。 Cycloxygenase-2 plays an important role in many human tumorigenesis, and is overexpressed in breast cancer. Therefore, it is necessary to investigate the relationship between COX-2 and breast cancer, and to develop the desirable COX-2 inhibitor. These can privide a new antitumor method.
作者 韩晖 赵文新
出处 《国际外科学杂志》 2008年第8期561-564,共4页 International Journal of Surgery
关键词 环氧化酶-2 抑制剂 乳腺癌 COX-2 inhibitor breast cancer
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参考文献24

  • 1Timoshenko AV, Chakraborty C, Wagner GF, et al. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer[J]. Br J Cancer, 2006, 4(8) :1154-1163.
  • 2Singh B, Lucci A. Role of cyclooxygenase-2 in breast cancer[ J]. J Surg Res, 2002, 108( 1 ) :173-179.
  • 3Oliveira VM, Piato S, Silva MA. Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium[J]. Breast Cancer Res Treat, 2006, 95(3):235-241.
  • 4Brueggemeier RW, Quinn AL, Parrett ML, et al. Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens [ J ]. Cancer Lett, 1999, 140 (1-2) :27-35.
  • 5Cao Y, Pearman AT, Zimmerman GA, et al. Intracellular unesterified arachidonic acid signals apoptosis[J]. Proc Natl Acad Sci U S A, 2000, 7(21 ) :11280-11283.
  • 6Singh B, Lucci A. Role of cyclooxygenase-2 in breast cancer[ J]. J Surg Res, 2002, 108 ( 1 ) : 173-179.
  • 7Kundu N, Smyth MJ, Samsel L, et al. Cyclooxygenase inhibitors block cell growth, increase ceramide and inhibit cell cycle [ J ]. Breast Cancer Res Treat, 2002, 76( 1 ) :57-64.
  • 8Takahashi Y, Kawahara F, Noguchi M, et al. Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or-2 [ J ]. FEBS Letters, 1999, 460 ( 1 ) : 145-148.
  • 9Ruegg C, Zaric J, Stupp R, et al. Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality[J]. Ann Med, 2003, 35(7) :476-487.
  • 10郭贵龙,姚榛祥.环氧化酶-2在人乳腺癌中的表达及对肿瘤血管形成的影响[J].中华外科杂志,2004,42(20):1271-1272. 被引量:18

二级参考文献10

  • 1SambrookJ FritschEF ManiatisT.克隆化基因所表达蛋白质的检测与分析[A].金冬雁 黎孟枫 译.分子克隆实验指南 第3版[C].北京:科学出版社,1992.852-898.
  • 2Sawaoka H, Tsuji S, Tsujii M, et al. Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. Lab Invest, 1999, 79: 1469-1477.
  • 3Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad USA, 1997, 94:3336-3340.
  • 4Funato T, Kozawa K, Fujimaki S, et al. Increased sensitivity to cisplatin in gastric cancer by antisense inhibition of the her-2/neu (c-erbB-2 ) gene. Chemotherapy, 2001, 47: 297-303.
  • 5Half E, Tang XM, Gwyn K, et al. Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res, 2002, 62:1676-1681.
  • 6Ristimaki A, Sivula A, Lundin J, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res, 2002, 62: 632-635.
  • 7Costa C, Soares R, Reis-Filho JS, et al. Cyclooxygenase-2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol, 2002, 55: 429-434.
  • 8Schmitt F, Soares R. TGFα and angiogenesis. Am J Surg Pathol, 1999,23: 358-359.
  • 9郭贵龙 姚榛祥.P27、Ki—67联合检测对乳腺癌预后的意义[J].中华实验外科杂志,2002,19:273-273.
  • 10郭贵龙,姚榛祥,吴坚.环氧化酶-2基因在人乳腺癌中的表达及临床意义[J].中华医学杂志,2003,83(19):1661-1664. 被引量:38

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