核受体FXR依赖胆汁酸信号对胆汁酸代谢的调节

Farnesoid X receptor dependent bile acid signaling regulates bile acids metabolism

法尼酯衍生物X受体（famesoid Xreceptor，FXR）是核受体的超家族成员之一，在多种代谢途径中起着关键作用。胆汁酸是FXR的主要内源性配体，激活的FXR作用于靶基因后具有抑制胆汁酸的合成、吸收和促进分泌等作用。本文就FXR在胆汁酸代谢过程中的靶基因及其功能进行总结。

The Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily and has emerged as a key player in the control of multiple metabolic pathways. Bile acids are the major endogenous ligands for FXR, and by activating FXR have a variety of target genes, many of which are geared toward preventing synthesis and uptake and promoting excretion of bile acids. Here we summarized the latest results from studies on FXR target genes and functions in bile acids metabolism in this article.