期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

甘遂中麻风树烷型大环二萜类化学成分研究 被引量：7

Studies on macrocyclic jatrophane diterpenes of Euphorbia kansui
下载PDF
导出
摘要 目的:研究甘遂Euphorbia kansui中麻风树烷型大环二萜类的化学成分。方法:采用硅胶、凝胶等色谱技术进行分离,通过NMR等波谱学方法鉴定化合物结构。结果:分离并鉴定出3个麻风树烷型大环二萜,分别为甘遂宁D1(kansuinin D1,1),甘遂宁D(kansuinin D,2)和甘遂宁A(kansuinin A,3)。结论:其中化合物1为新化合物。 Objective： To study macrocyclic jatrophane diterpenes of Euphorbia kansui. Method： The compounds were isolated and purified by various column chromatographic methods. Structures were elucidated by spectroscopic analyses. Result： Three macrocyclic jatrophane diterpenes were isolated from E. kansui and were characterized as kansuinin D1 （1）, kansuinin D （2）, kansuinin A （3）. Conclusion： Kansuinin DI （1） was a new compound.
作者 陈云利 袁丹 徐鑫 傅宏征
机构地区 北京大学医学部天然药物及仿生药物国家重点实验室 沈阳药科大学中药学院
出处 《中国中药杂志》 CAS CSCD 北大核心 2008年第15期1836-1839,共4页 China Journal of Chinese Materia Medica
基金 国家自然科学基金项目(30772639)
关键词 甘遂 麻风树烷型 大环二萜 Euphorbia kansui jatrophane macrocyclic diterpenes
分类号 R284.1 [医药卫生—中药学]
  • 相关文献

参考文献9

  • 1江苏新医学院.中药大辞典[M].上海:上海科学技术出版社,1978.2031.
  • 2Kondo K, Sugi M. Cancer therapy in modern China[M]. Tokyo: Shi Zen Sha, 1977:254.
  • 3Wu T S, Li Y M, Hirana M, et al. Antitumor agents, 119^1. Kansuiphorins A and B, two novel antileukemie diterpene esters from Euphorbia kansui[ J]. J Nat Prod, 1991,54:823.
  • 4Pan D J, Hu C Q, Chang J J, et al. Kanuiphorin C and D, cytotoxic diterpenes from Euphorbia kansui [ J ]. Phytocehmistry,1991,30 : 1018.
  • 5Fujiwara M, Ijichi K, Konno K. Ingenol derivatives, ingredient of kansui, are highly potent inhibitor of HIV[ J]. Antiviral Res, 1995,26(3) :228.
  • 6郑维发.甘遂醇提物中4种二萜类化合物的体内抗病毒活性研究[J].中草药,2004,35(1):65-68. 被引量：46
  • 7Wang L Y, Wang N Y, Yao X S, et al. Diterpenes form the roots of Euphorbia kansui and their in vitro effects on the cell division of xenopus(2) [J]. Chem Pharm Bull, 2003,51(8) :935.
  • 8Uemura D, Hirata Y. The structure of kansuinin A, a new multioxygenatedditerpene [ J ]. Tetra Lett, 1975 : 1697.
  • 9Qin Pan, Fanny C F Ip, Nancy Y Ip, et al. Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay[ J]. J Nat Prod, 2004,67:1548.

二级参考文献9

  • 1[1]Wu T S, Lin Y M, Haruna M, et al. Antitumor agents,119. Kansuiphorins A and B, two novel antileukemic diterpen esters from Euphorbia kansui [J]. J Nat Prod, 1991, 54(3): 823-829.
  • 2[2]Uemura D, Hirata Y. The structure of Kansuinine A, a new multi-oxygenated diterpene from Euphorbia kansui [J]. Tetrahedron Letters, 1975, (21): 1697-1700.
  • 3[3]Uemura D, Katayama C, Uno E, et al. Kansuinine B, a novel multi-oxygenated diterpene from Euphorbia kansui Liou[J]. Tetrahedron Letters, 1975, (21): 1703-1706.
  • 4[4]Pan D J, Hu C Q, Chang J J, et al. Kansuiphorin-C and kansuiphorin-D, cytotoxic diterpenes from Euphorbia kansui[J]. Phytochemistry, 1991, 30(3): 1018-1020.
  • 5[6]Zheng W F, Cui Z, Zhu Q. Cytotoxicity and antiviral activity of the compounds from Euphorbia kansui [J]. Planta Med, 1998, 64(8): 754-756.
  • 6[7]Ott H H, Hecker, E. Highly irritant ingenane type diterpene esters from Euphorbia kansui Liou [J]. Experientia, 1981,37:88-91.
  • 7[8]Matsumoto T, Cyong J C, Yamada H. Stimulatory effects of ingenols from Euphorbia kansui on the expression of macrophage Fc recepter [J]. Planta Med, 1992, 58: 255-258.
  • 8[9]Chen Q. Methodology in Pharmacology Study on Chinese Materia Medica [M]. Beijing: People's Medical Publishing House, 1993.
  • 9[10]Paglia P, Chioldoni C, Rodolfo M, et al. Murine dendrtic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo [J]. J Exp Med,1996, 83: 317-322.

共引文献48

同被引文献103

引证文献7

二级引证文献98

中国中药杂志
2008年 第15期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部