前列解毒胶囊治疗慢性前列腺炎的临床疗效评价

Clinical effect of Qianliejiedu capsule on the treatment of chronic prostatitis

目的探讨前列解毒胶囊治疗慢性前列腺炎(CP)的疗效。方法选择在我院门诊部就诊,病程在3个月以上的慢性前列腺炎患者328例,口服前列解毒胶囊4粒/次,2次/d,疗程2个月,以NIH-慢性前列腺炎症状指数(NIH-CPSI)和前列腺按摩液(EPS)白细胞计数及卵磷脂小体的多少为疗效的指标,进行治疗前后疗效比较。结果按要求完成治疗的患者305例,NIH-CPSI总评分治疗前后分别为(25.6±5.8)分和(12.7±5.6)分,平均降低12.5分,两者比较,差异有统计学意义(P<0.01);症状评分治疗前后分别为(16.5±4.8)分和(7.9±2.8)分,平均降低8.6分,两者比较,差异有统计学意义(P<0.01);生活质量评分治疗前后分别为(9.8±3.3)分和(4.1±2.3)分,平均降低5.1分,两者比较,差异有统计学意义(P<0.01)。自觉症状完全消失的154例,症状未完全消失的109例,自觉症状无任何改善的42例。EPS中白细胞计数治疗前后分别为(35.5±12.7)个/HP和(8.3±13.6)个/HP,卵磷脂小体治疗前后平均分别为(+)和(+++)。治愈者154例(50.5%),有效者109例(35.8%),无效者42例(13.7%)。总有效率86.3%。未见肝肾功能异常及不良反应发生。结论前列解毒胶囊治疗慢性前列腺炎安全、有效、无明显不良反应。

Objective To explore the effectiveness of Qianliejiedu capsule in the treatment of chronic prostatitis. Methods A total of 328 chronic prostatitis patients whose disease course （at least 3 months）were enrolled in this study, and they received a treatment of oral Qianliejiedu capsule for 2 months（4 tablets, 2 times per day）. NlH-chronic prostatitis symptom index（NIH-CPSI） and counting leukocytes in expressed prostatic secretions（EPS） were applied to assess the effectiveness. Results 305 cases accomplished treatment on request. Overall scores of NIH-CPSI in 305 patients before and after treatment were （25.6±5.8） and （12.7±5.6） respectively, which score decreased 12.5 averagely （P〈0.01）, and the scores of symptom were （16.5±4.8） and （7.9±2.8） respectively, which score also decreased 8.6 averagely （P〈0.01）, the scores for quality of life were （9.8±3.3） and （4.1±2.3） respectively, which score decrease 5.1 averagely （P〈0.01）. There were 154 patients with no subjective symptom and 109 patients with mild symptom, as well as 42 patieuts with no change symptom. The number of leukocytes in EPS pre and post treatment were （35.5±12.7）/HP and （8.3±13.6）/HP, respectively and the quality of the lecithin small body was （＋） and （＋＋＋） respectively. After treatment, 154 patients （50.5%） were cured, 109 patients （35.8%） effective and 42 patient （13.7%） no effect. Total effective rate was 86.3%. The apparent side effect was not observed in all treated patients including kidney and hepatic function. Conclusion Qianliejiedu capsule was a safe and effective medicine for treatment of chronic prostatitis.