溶血磷脂酸酰基转移酶β与肿瘤关系研究进展

Relationship between Lysophosphatide Acid Acyltransferase β and Tumor——Review

磷脂酸(PA)是一种多功能的生物活性磷脂。研究证实:溶血磷脂酸酰基转移酶β(lysophosphatidic acidacyltransferaseβ,LPAATβ)催化溶血磷脂酸(LPA)产生的PA与肿瘤细胞内多种信号途径的活化有关,参与了肿瘤细胞的增殖、凋亡、迁移、侵袭、呼吸爆发及细胞因子表达释放。LPAATβ在肿瘤组织中的表达显著增加以及抑制LPAATβ表达在体内外抗肿瘤(实体瘤和血液肿瘤)的作用研究取得的效果,提示以LPAATβ为靶点对肿瘤进行干预将成为重要的抗肿瘤治疗策略之一。本文就溶血磷脂酸酰基转移酶β与肿瘤治疗的相关基础及临床前研究进行综述。

Phosphatide acid （PA） is a kind of multifunctional bioactive phospholipid. It has been proved that PA produced by lysophosphatide acid acyltransferase （ LPAATβ ） was involved in several signalling pathways in tumor cells, leading to the proliferation, apoptosis, migration, invasion, respiratory burst, expression and release of cytokine form tumor cells. The fact that expression of LPAATβ was higher in tumor tissues than in their homologous normal tissues, and that antitumor effect of inhibitng LPAATβ on solid tumor and hematological malignancy suggested that the targeting LPAATβ would be a promising method of antitumor treatment. In this paper, the relevant basic and preclinical researches of LPAATβ on antitumor treatment were summarized.