控制牙菌斑对胃粘膜幽门螺旋杆菌检出率的影响

Control of dental plaque on helicobacter pylori in gastric mucosa

目的通过检测胃粘膜幽门螺旋杆菌(HP),观察控制牙菌斑对胃粘膜HP检出率的影响,探讨口腔和胃内HP的相关性。方法将根除胃内HP的患者108例分为试验组(n=56)和对照组(n=52)。试验组行彻底的牙菌斑控制,对照组未行牙菌斑控制或控制失败。半年后均行胃镜复查,并行病理检查和快速尿素酶试验检测胃内HP,确定其检出率。结果试验组56例患者中胃HP阳性者11例,检出率为19.6%;对照组52例患者中胃HP阳性者42例,检出率为80.8%,试验组胃粘膜中HP的检出率明显低于对照组(P<0.05)。结论口腔与胃HP感染之间具有明显相关性。提示治疗HP相关性胃病时,应注意口腔卫生,控制牙菌斑。

Objective To explore the relationship between oral and gastric mucosa helicobacter pylori （H. pylofi）. Methods 108 patients without H. pylori in their gastric mucosa were assigned into the experimental group （ n = 56） and the control group （ n = 52）. Dental plaque was completely controlled in the experimental group and was not controlled or not successfully controlled in the control group. All patients re-underwent endoscopies after haft a year. By endoscoples, biopsies were taken from the gastric mucosa. Histological examination and rapid Urease test were used to determine the presence of H. pylori. Results H. pylori was found in 11 cases （19.6%） in the experimental group and 42 cases （80.8%） in the control group. The presence of H. pylori was significantly lower in the experimental group than that in the control group （ P 〈 0.05）. Conclusion There are significant relationships between oral and gastric H. pylori infection, indicating dental plaque should be controlled in treatment of H. pylori-related gastric diseases.