联合用药后替硝唑乳汁浓度与时间关系

Relationship between time and concentration of Lacto-tinidazole after drug combination

目的探讨联合用药后替硝唑乳汁浓度与时间关系,为临床合理用药并指导产妇母乳喂养新生儿提供依据。方法采用自身对照方法,以甲硝唑为内标物质应用高效液相色谱(HPLC)法测定同一患者应用替硝唑(800 mg/d)23、d后不同时间乳汁浓度。结果替硝唑乳汁浓度存在较大个体差异,同一患者静脉滴注替硝唑2、3 d(800 mg/d)后02、、46、、81、8、24 h乳汁浓度差异有统计学意义(P<0.05)。结论患者连续应用替硝唑3 d,体内有药物蓄积现象,应尽可能减少替硝唑用药次数,减少新生儿被动用药。

Objective To offer a basis for rational clinical use of finidazole and to guide breast feeding to neonates. Method The Lacto-tinidazole concentrations at different times after intravenous drip tinidazole （800 mg/d） were determined by HPLC using the self-control method. Results Lacto-tinidaz, ole concentration was statistically different among different patients and 0, 2, 4, 6, 8, 18 and 24 h（ P 〈 0.05）after the same patient received intravenous drip of tinidazole after two or three days, Conclusion Tinidazole can be accumulated in patients after three days usage, So it should be cautiously used so as to reduce neonates passive absorption.