复方环丙孕酮联合二甲双胍治疗多囊卵巢综合征疗效观察

The clinical effects of metformin combined with cyproterone therapy on polycystic ovary syndrome

目的观察复方环丙孕酮联合二甲双胍治疗多囊卵巢综合征（PCOS）的疗效。方法选择门诊就诊的多囊卵巢综合征患者90例，复方环丙孕酮联合二甲双胍治疗3个周期，测定患者血清黄体生成素（LH）、黄体生成素／卵泡刺激素（LH／FSH）和睾酮（T），测定腰／臀比值（WHR），并对治疗前后进行比较。结果治疗后LH、LH／FSH、T及WHR均较治疗前明显降低（P〈0．05或P〈0．01），治疗后月经均来潮且规则，痤疮、多毛症状也减轻。结论复方环丙孕酮联合二甲双胍是治疗多囊卵巢综合征的理想方法。

Objective To observe the curative effects of metformin combined with cyproterone therapy on polycystic ovary syndrome（PCOS）. Methods Ninety diagnosed PCOS patients were treated. The serum luteinizing hormone（LH）, luteinizing hormone and follicule stimulating hormone（LH/FSH） ratio and T, waist hip ratio（WHR） of the patients before therapy were compared with using metformin combined with cyproterone three cycles. Results A significant reduction（P〈 0.05 or P〈 0.01 ） in LH, LH/FSH, T and WHR of patients after the therapy was observed. Menses became regular after the therapy, and acne and hirsutism mitigated. Conclusion Metformin combined with eyproterone is a perfect means to treat polycystic ovary syndrome（PCOS）.