利托君联合丹参治疗胎儿生长受限疗效观察

Effect of ritodrine hydrochloride combined with radix salviae miltiorrhizae on fetal growth restriction

目的观察盐酸利托君与丹参联合应用治疗胎儿宫内发育迟缓的临床疗效。方法将62例胎儿生长受限孕妇随机分为实验组（n=31）和对照组（n=31），对照组用脂肪乳剂250ml静脉滴注，1次／3d，连用1周；10％葡萄糖注射液500ml＋辅酶A100U、三磷酸腺苷40mg、维生素C2g静脉滴注，每日1次；低分子右旋糖酐＋复方丹参注射液10ml，静脉滴注，每日1次，共10d。实验组除上述治疗外，再每天加用盐酸利托君100mg静脉滴注，10d为1个疗程。治疗后测量宫高、腹围、体质量及行超声检查了解胎儿的双顶径、头围、腹围、新生儿出生体质量和胎盘重量。结果实验组孕妇的测量指标及新生儿出生体质量和胎盘重量明显高于对照组，差异有统计学意义。结论盐酸利托君联合丹参能改善子宫胎盘血流，促进细胞代谢，改善微循环，促进胎儿生长发育。

Objective Ritodrine hydrochloride（RH） combined with radix salviae miltiorrhiza（RSM） is applied to treat fetal growth ristriction（FGR）. Curative effect was recorded during observation. Methods 62 pregnant women with slowly growing fetuses were divided into two groups randomly. Group A（test group） ：including 31 pregnant women who received RH combined with RSM treatment, Group B（control group） ：including the other 31 pregnant women who only received RSM treatment. Group B received 250ml of fat emulsion injection. One time every three days within one week. At the same time,group B also received injection of 500ml 10 % dextrose, coenzyme A 100U,ATP 40mg,vitamin C 2g,dextran-40 and compound salvia injection 10ml one time a day,ten days in all. Besides the above-mentioned medicament for group B,group A received RH 100ml injection every day. Ten days was a period of treatment. After the treatment, uterine height, abdominal circumference, weight were measured and biparietal diameter, head circumference, abdominal circumference were checked by B-type ultrasonic inspection. After birth,weight of the baby and weight of placenta were measured too. Results Measurement indexes from group A, weight of the new-born baby and weight of placenta are obviously higher than those from group B. Conclusion RH combined with RSM can obviously extend blood vessel, loose placenta, improve blood circulation, accelerate cell metabolism,make microcirculation better, reduce permeability of capillary vessel, keep placenta＇s function and help foetus＇ growth.