纳洛酮治疗新生儿缺氧缺血性脑病临床观察

Clinical Observation on Naloxone in the Treatment of Hypoxic Ischemic Encephalopathy in Newborns

目的:探讨纳洛酮治疗新生儿缺氧缺血性脑病的临床疗效。方法:将72例新生儿缺氧缺血性脑病患儿随机分为两组,对照组34例,采用常规治疗,治疗组38例,在常规治疗的基础上加用纳洛酮治疗5—7天,观察疗效,并于两周后分别对患儿进行行为神经测定(NBNA)评分。结果:治疗组显效率、总有效率及降低后遗症发生率方面疗效均优于对照组。结论:在常规治疗基础上加用纳洛酮治疗新生儿缺氧缺血性脑病,疗效显著,可降低后遗症发生率,未见明显不良反应发生。

Objective： To discuss the effect of naloxone in the treatment of hypoxic ischemic encepnalopatny in newborns, Methods： 72 newborns with hypoxic ischemic encephalopathy were randomly divided into two groups. 34 cases in control group were received conventional therapy, while 38 cases in treatment group were added naloxone for 5--7days. The effect was observed. And the NBNA was performed after two weeks. Results： The treatment group was superior to control group in the obvious effective rate, the total effective rate and the reduction of incidence of sequela and the like. Conclusions： The treatment of hypoxic ische- role encephalopathy by naloxone on the basis of conventional therapy can achieve good effect and reduce the incidence of sequela with no obvious side effect.