苦参黄芪注射液联合顺铂胸腔内注射治疗肺癌胸水疗效观察

Intrathoracic administration of Kushenhuangqi Injection combined with cisplatin in treatment of malignant pleural effusion

将71例肺癌恶性胸水患者分为治疗组（36例）和对照组（35例），均在胸腔穿刺置管引流胸水后胸腔内注射顺铂，治疗组加用苦参黄芪注射液。治疗后治疗组有效率显著高于对照组，白细胞下降及恶心、呕吐等不良反应明显减轻。表明苦参黄芪注射液治疗肺癌恶性胸水能够提高化疗药物疗效，并能明显减轻化疗药物的不良反应。

Kushenhuangqi Injection is made from Chinese herb medicine flavescent sophora and astragalus roots. Seventy-one patients with malignant pleural effusion were randomly divided into two groups. 36 patients were treated with both intrathoracic Kushenhuangqi Injection and chemotherapeutic agent cisplatin （treatment group） and 35 patients were treated with cisplatin alone. The response rate of treatment group was significantly higher than that of control group （31/36 vs 20/35, u = 3. 020, P 〈 0. 01 ）. The rate of adverse reaction （leucopenia, nausea, vomiting etc. ） in treatment group was significantly lower that that of control group. The results indicate that Kushenhuangqi Injection can enhance the therapeutic effect of chemotherapeutic agent and reduce its adverse reaction in treatment of malignant pleural effusion caused by carcinoma of the lungs.