乳腺癌钼靶X线表现与抑癌基因PTEN的相关性研究

Correlative Study on Mammographic Features and PTEN of Breast Cancer

目的:探讨乳腺癌钼靶X线表现与抑癌基因PTEN的相关性。方法:对40例乳腺癌标本经免疫组织化学方法检测抑癌基因PTEN表达,并分析其与术前钼靶X线征象的相关性。结果:40例中钼靶X线表现为肿块并毛刺征30例(75.0%),有钙化15例(37.5%)。PTEN高表达者22例(55%)。结论:乳腺癌钼靶X线征象在一定程度上反映了P53基因表达状态。

Objective： To investigate the correlation between the molbdemum target mammographic features and PTEN gene of breast cancer. Methods： The mammographic features of 40 patients with breast cancer were studied, and compared with PTEN gene stained with immunohistochemical technique. Results： Of 40 cases, the calcification was in 30 cases（75% ）, spicule sign in 15 cases（37.5% ）. The expsession status of PTEN gene was strong positive in 22 cases （55 % ）. Conclusion： The molybdenum target mammographic features of breast cancer can reflect the expression status of PTEN gene.