阿奇霉素间断重复给药对支原体肺炎复发的阻止作用

Impeding Effect of Repeated Intermittent Administration of Azithromyzin on Recurrence of Mycoplasma Pneumonia

目的：观察阿奇霉素疗效并探讨阿奇霉素间断重复给药对支原体肺炎复发的阻止作用。方法：将108例支原体肺炎患儿随机分为治疗组和对照组,治疗组间断重复口服阿奇霉素3～4周;对照组连续口服阿奇霉素5～7 d。两组患儿均常规对症治疗。结果：两组患儿治疗7 d后疗效一致,无显著性差异（P〉0.05）;但2月后复查胸片治疗组正常率高于对照组,治疗组复发率明显低于对照组,有极显著性差异（P〈0.01）。结论：间断重复使用阿奇霉素3～4周较连续应用阿奇霉素5～7 d对支原体肺炎再次复发有更佳阻止作用。

Objective： To observe the clinical result of azithromycin as Well as to investigate the impeding effect of repeated intermittent administration of azithromycin on the recurrence of mycoplasma pneumonia. Methods： 108 mycoplasma pneumonia children were randomly divided into treatment group （A） and contrast group （B）. Group A was intermittently administered azithromyzin orally throughout a period of 3 - 4 weeks, while group B was administered azithromycin regularly for a period of 5 - 7 days. Results： After a week , the curative effects of the two groups were similar （ P 〉 0.05 ） ; however, after two months, chest radiographs showed a obvious difference between the two groups, with group A had lower recurrence rate than group B （P 〈0.01）. Condusion： Repeated intermittent administration of azithromycin over a period of 3 -4 weeks could impede the recurrence of mycoplasma pneumonia, and better than regular consumption of azithromycin for 5 - 7 days.