酞胺哌啶酮治疗多发性难治性骨髓瘤的临床研究

Thalidomide in the treatment of refractory multiple myeloma

目的探讨酞胺哌啶酮治疗多发性难治性骨髓瘤（MM）的疗效及不良反应。方法对12例MM患者采用酞胺哌啶酮治疗，起始剂量为100mg／d，根据患者耐受情况逐渐加量，最高可达400mg／d。结果75％的患者对治疗有效，其中3例完全缓解，3例部分缓解，3例治疗进步，2例无效，1例不能耐受治疗而退出。12例患者均有不同程度的不良反应，如嗑睡、便秘、头晕、皮疹等。结论酞胺哌啶酮治疗多发性骨髓瘤有效，不良反应可耐受。

Objective To investe the efficacy and side effects of thalidomide in the treatment of refractory multiple myeloma. Methods There were refractory multiple myeloma patients 12 cases, thalidomide was given to those patients at the starting dose of 100 mg/d and added the dose 100 mg/d each week until the maximum of 400 mg/d. Results Among the 12 patients,3 cases achieved completely remission,3 cases achieved partial remission,4 cases improved and 2 cases had no effect. The total response rate was 75%. The side effects were drow siness,constipation and debility. Conclusion It＇s effective in the treatment of refractory multiple myeloma.