凯西莱片预防抗结核药物肝损害的临床观察

Clinical study on preventing medicamentous liver lesion induced by antituberculosis drugs of tiopronin tablets

目的观察凯西莱片对抗结核药物所致肝损害的防治效果。方法初治肺结核患者194例，予以2HRZS（E）／4HR方案抗结核化疗，治疗组98例，全程加服凯西莱片；对照组96例，全程加服葡醛内酯。结果治疗组出现肝损害7例（7．14％），其中HBsAg阳性患者出现肝损害3例（11．1％），老年患者2例（9.52％）；对照组出现肝损害28例（29.17％），其中HBsAg阳性患者出现肝损害12例（48．0％），老年患者5例（23．8％）。结论凯西莱片在预防抗结核药物所致肝损害中疗效显著，尤其是HBsAg阳性患者及老年肺结核患者。

Objective To determine the preventive efficacy of tiopronin tablets on medicamentous liver lesion by antitubereulosis drugs. Methods One hundred and ninety - four intially - treated pulmonary tuberculosis patients who received the regimen of 2HRZS（E）/4HR were randomly separated into two groups：observe group ,98 cases, supplemented with tiopronin tablets. Control group, 96 cases, received glucurolactone. Results There were 7 cases who had liver damage in observe group（7.14% ） , 3 cases with HBsAg positive （ 11. 1% ）, 2 cases were old people ; there were 28 cases who had liver damage in control group （29.17%）, 12 cases with HBSAg positive（48.0% ） ,5 cases were old people. Conclusion Tiopronin tablets is effective in preventing cause by anti - tuberculosis drugs, HBsAg positive and old patient＇ s liver function should be monitored in the early period of centi - tuberculosis treatment.