婴幼儿肝炎综合征血清总胆汁酸的表达和意义

Signification of serum total bile acid determination in infantile hepatitis syndrome

目的研究血清总汁酸（TBA）在婴幼儿肝炎综合征中的表达及其临床意义。方法采用全自动生化分析技术，测定肝炎综合征患儿84例（感染组）与非肝胆疾病患儿45例（对照组）的TBA水平，并进行比较，其将感染组的TBA表达水平进行比较。结果对照组的TBA表达明显低于感染组的TBA，两组比较差异有统计学意义（P〈0．01），而与丙氨酸氨基转移酶（ALT）有显著相关性（P〈0．01），且TBA的阳性率高于谷氨酸氨基转移酶（ALT）的阳性率（P〈0．05）。结论血清TBA的表达在反映肝功能损伤方面是一个敏感的指标，对婴幼儿肝炎综合征患儿的早期诊断、治疗、改善预后有重要临床意义。

Objective To explore the significance of serum total bile acid （ TBA ） in the diagnosis and treatment of infantile hepatitis syndrome. Methods Serum TBA and other liver function related items were determined with automtic enzymatic assay techniques in 84 with infantile hepatitis syndrome patients （ age 21 days - 7 years ） and 45 normal infants （ age 20 days - 7 years）. Results The serum TBA level of 95% patients was abnormal and the average values were（ 54 ± 12 ） μmol/L, in the control group the serum TBA level were （ 9 ± 5 ） μmol/L The TBA level was well related to those of ALT,TBiL, DBil and TBA was better than others in sensitivity and specificity. Conclusion Serum TBA level is important in evaluting the diagnosis, treatment and prognosis of infantile hepatitis syndrome.