河南汉族初诊2型糖尿病患者血清脂联素与瘦素水平的关系

Relationship between serum adiponectin and leptin levels in newly diagnosed patients with type 2 diabetes of the Han nationality in Henan

目的探讨河南汉族初诊2型糖尿病患者（DM）血清脂联素与瘦素水平的关系。方法采用放射免疫分析法（RIA）测定初诊2型DM患者和正常健康人血清脂联素与瘦素水平，并分析与甘油三酯（TG）、腰围／身高比值（WHtR）、糖负荷后2h血糖（2hPG）的关系。结果①2型DM患者血清脂联素水平明显低于正常对照组，而瘦素水平高于对照组。②相关性研究显示，血清瘦素水平与脂联素水平呈负相关，瘦素水平与WHtR、TG、2hPG呈正相关；脂联素水平与WHtR呈负相关，与TG、2hPG无明显相关性。③多元线性回归分析表明WHtR是影响血清瘦素水平与脂联素水平的独立相关因素。结论河南汉族初诊2型DM患者血清脂联素水平降低、瘦素水平升高。

Objective To study the relationship between serum adiponectin and leptin levels in newly diagnosed patients with type 2 diabetes of the Han nationality in Henan. Methods Serum adiponectin and leptin levels were assayed by radioimmunoassy （RIA） in newly diagnosed patients with type 2 diabetes and controls. The relationship of serum adiponectin levels with leptin, triglycerid,WHtR and 2 h PG were analyzed. Results The serum adiponectin levels was lower significantly than those of normal controls, and the leptin levels increased significantly than control group. There was negatively correlation between leptin level and adiponectin, but it was positively correlated with WHtR, triglycerid and 2 h PG. There was negatively correlation between adiponectin level and WHtR, but there was no correlation between the adiponectin level and other indexes such as TG,2 h PG. Multiple regression analysis showed that WHtR was independent related factors in influencing serum adiponectin and leptin levels. Conclusion The serum leptin level increased, but the adiponectin levels decreased in newly diagnosed patients with type 2 diabetes of the Han nationality in Henan.