轮状病毒感染腹泻致肝脏损害近期临床分析

The recent clinical analysis of rotavirus diarrhea leading to hepatic lesion

目的探讨轮状病毒感染腹泻致患儿肝脏损害及近期临床相关因素的关系。方法153例腹泻患儿分为轮状病毒腹泻组（82例）和对照组（71例）。进行①转氨酶[天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）]检测。②大便轮状病毒的ELISA和PAGE电泳检测。③血清及淋巴细胞的分离。结果①轮状病毒腹泻组ALT、AST升高者均较对照组明显增多，且程度较对照组重。②82例轮状病毒腹泻患儿ALT的升高与相关临床表现（腹泻天数、腹泻程度、脱水程度、发热天数、发热程度和大便排毒）的关系无明显相关。③82例血清中2例检出轮状病毒，28例淋巴细胞中6例检出轮状病毒，分属8个患儿。血清阳性者未检测淋巴细胞，淋巴细胞阳性者血清未检出。8例患儿中，4例ALT、AST显著升高，4例轻度升高。结论轮状病毒腹泻可伴有病毒血症，并致肝脏损害。

Objective To probe the rotavirus diarrhea leading to hepatic lesion and the relation between recent clinical correlative factors and hepatic lesion. Methods 153 patients of diarrhea were divided into the rotavirus diarrhea group and the control group, We detected their transaminase, the rotavirus from stool through ELISA and PAGE electrophoresis, and the rotavirus from serum and lymphocyte. Results The patients with high ALT and AST and the degree of the raise in the rotavirus diarrhea group were significantly more than the control group. There were no significantly relativity between the raise of ALT and correlative clinical manifestations （ the day of diarrhea, the degree of diarrhea, the degree of dehydration, the day of fever, the degree of fever and the amount of rotavirus in stool） in the rotavirus diarrhea group. In the rotavirus diarrhea group, rotavirus were detected in 2 patients＇ serum and 6 patients＇ lymphocyte. The lymphocyte weren＇ t detected in the positive serum. Rotavirus weren＇ t detected in serum in the positive lymphocyte. In the 8 patients, the raise of transaminase were significantly in 4 patients and slightly in the others. Conclusion Rotavirus diarrhea can accompany by virusemia and lead to hepatic lesion.