我院大肠埃希菌临床耐药分析及对策

Clinical resistance analysis and countermeasures of escherichia coli from our hospital

目的了解我院大肠埃希菌的分布及耐药情况，为临床合理用药提供参考。方法对我院细菌室从2002年至2005年临床各科标本中分离的724株大肠埃希菌对18种抗生素进行药敏试验。结果大肠埃希菌对抗菌素耐药率大于50％：氨苄西林87．3％、复方新诺明81．5％、头孢拉定70．6％、庆大霉素70．4％、哌拉西林66．0％、头孢噻肟61．5％、头孢呋辛61．5％、头孢曲松58．8％，耐药率高，对亚胺培南等耐药率最低为0．3％。结论大肠埃希菌对多种抗菌素具有高度耐药性，应根据药敏结果合理选用抗菌素，重视细菌培养，减少耐药菌株，减少医院感染。

Objective To investigate the distribution and antibiotic resistance of escherichia coli in our hospital and offer suggestions for clinic. Methods The antibiotics susceptibility to eighteen kinds of antibiotics were tested. Data were collected from 724 bacteria escherichia coli strains isolated from clinical specimens from Jan,2002 to Dec,2005 in our hospital. Results The resistance rate were higher than 50% ： ampicillin, sulfamethoxazole, cephalothin, gentamicin, piperacillon, cefotaxime, cefuroxime,ceftriaxone were 87.3% ,81.5% ,70.6% ,70.4% ,66.0% ,61.5% ,61.5% ,58.8% respectively. The resistance rate of imipcnern was the lowest. Resistance rate of imipenem was 0.3%. Conclusion It shows high resistance to several kinds of antibiotics from our hospital. We should pay attention to drug sensitivity tests, reduce resistance strains and reduce hospital infection.